β-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

By K. Pike, G. Savage, V. Villemagne, S. Ng, Simon A. Moss, P. Maruff, Chester A. Mathis, William E. Klunk, Colin L. Masters, C. Rowe. 2007

745 citations recorded by the source corpus.

Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with Abeta burden in non-demented persons and in AD patients is unclear. We examined this relationship using 11C-PIB-PET as a quantitative marker of Abeta burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a 11C-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to Abeta burden. Ninety-seven percent of AD, 61% of MCI and 22% of HA cases had increased cortical PIB binding, indicating the presence of Abeta plaques. There was a strong relationship between impaired episodic memory performance and PIB binding, both in MCI and HA. This relationship was weaker in AD and less robust for non-memory cognitive domains. Abeta deposition in the asymptomatic elderly is associated with episodic memory impairment. This finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical PIB binding are on the path to Alzheimer's disease. The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Abeta deposition are warranted.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/3929478a81980053fb36774103cdc10db555e2d9

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Citations in the corpus

Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. (2009, methodology): “We choose to quantify Ab burden by averaging values across multiple cortical areas, an approach that has been employed by many other groups (Fagan et al., 2006; Mintun et al., 2006; Pike et al., 2007; Rowe et al., 2007; Fotenos et al., 2008; Jack et al., 2008b).”
Longitudinal Changes in Cortical Thickness Associated with Normal Aging (2010, background): “In the context of recent neuroimaging studies using the amyloid tracer 11C[PIB] to study in vivo burden of fibrillar amyloid in the brain, the pattern of decline in cortical thickness observed in the current study appears to be somewhat similar to that of amyloid accumulation in older individuals, a”
Couples as socially distributed cognitive systems: Remembering in everyday social and material contexts (2014, background): “Such a framework provides one way of interpreting the fact that up to 30% of older individuals who appear cognitively healthy and retain their mental and memory capacities actually have significant neural signs of dementia (Morris et al., 2004; Pike et al., 2007).”
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. (2008, background): “(Pike et al., 2007) who found poorer performance on memory tests in high PiB vs.”
Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. (2010, neutral): “Biologic markers such as brain imaging of amyloid or brain volume measurement are also limited with regard to specificity for dementia because older subjects may show evidence of AD (eg, amyloid deposition) without cognitive impairment.(39) It is unresolved whether these subjects will eventually dev”
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease (2009, methodology): “PiB imaging methodology has been described previously (Pike et al., 2007).”
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. (2010, result): “Our data suggest that this is a rare occurrence. ur findings in the MCI and HC groups are also in accord with revious reports, with 2 thirds of the MCI and 1 third of the HC articipants presenting with high PiB retention (Aizenstein et l., 2008; Pike et al., 2007; Rowe et al., 2007).”
Amyloid deposition is associated with impaired default network function in older persons without dementia (2009, background): “…1992; Bennett et al., 2006; Morris et al., 1996), recent PiB-PET studies have reported amyloid deposition in significant percentages of nondemented older subjects (Aizenstein et al., 2008; Buckner et al., 2005; Gomperts et al., 2008; Johnson et al., 2007; Mintun et al., 2006; Pike et al., 2007).”
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011, result): “There have been variable reports in the previously published data thus far, regarding whether Aβpositive individuals demonstrate lower neuropsychological test scores at the time of biomarker study [50–54], which may represent heterogeneity in where these individuals fall on the preclinical continuum”