The Centiloid Project: Standardizing Quantitative Amyloid Plaque Estimation by PET

By William E. Klunk, Robert Koeppe, J. Price, T. Benzinger, Michael D. Devous, William J Jagust, K. Johnson, Chester A. Mathis, D. Minhas, Michael J. Pontecorvo and 3 more. Alzheimer's & Dementia, 2014

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Although amyloid imaging with PiB‐PET ([C‐11]Pittsburgh Compound‐B positron emission tomography), and now with F‐18‐labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named “Centiloids.” Basically, we describe a “standard” method of analyzing PiB PET data and then a method for scaling any “nonstandard” method of PiB PET analysis (or any other tracer) to the Centiloid scale.

Subfields: Physiology, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/325aa110524553fd90a217bab307818055df746b

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Citations in the corpus

Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria (2016, background): “The “centiloid” (CL) has been proposed as unit of measure of this 100-point unified scale for all Ab imaging tracers used [72].”
OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease (2019, neutral): “In order to provide standard quantification of amyloid analysis across lab protocols and tracers, the Centiloid scale has been developed to convert amyloid PET data to a 0-100 scale 52 .”
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis (2019, methodology): “Amyloid PET Centiloid was used to combine PiB and AV45 data on a similar scale.(26,27)”