Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

By Eric M. Reiman, Kewei Chen, Xiaofen Liu, D. Bandy, Meixiang Yu, Wendy Lee, Napatkamon Ayutyanont, J. Keppler, Stephanie A. Reeder, J. Langbaum and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2009

740 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/50d5adab23ba1a800626a6f613f94a2c667b07e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Holtzman
2. Reisa A. Sperling
3. Clifford R. Jack Jr.
4. G. Bu
5. J. Long

In Physiology

1. D. Holtzman
2. J. Herz
3. G. Bu
4. Reisa A. Sperling
5. Clifford R. Jack Jr.
6. Yaakov Stern
7. William H. Thies
8. P. Aisen

In Psychiatry and Mental health

1. D. Holtzman
2. Clifford R. Jack Jr.
3. Yaakov Stern
4. William H. Thies
5. Reisa A. Sperling
6. David S. Knopman
7. P. Aisen
8. Thomas J. Montine

Citations in the corpus

• BRAIN FUEL METABOLISM, AGING AND ALZHEIMER’S DISEASE (2010, background): “Consensus on definitions is emerging [60,61] and brain metabolism is being studied [62,63] in pre-clinical or prodromal forms of AD.”
• Introduction to Revised Criteria for the Diagnosis of Alzheimer’s Disease: National Institute on Aging and the Alzheimer Association Workgroups (2011, background): “Similarly, genetic at-risk cohorts demonstrate evidence of Ab accumulation many years before detectable cognitive impairment [38–41].”
• APOE Predicts Aβ but not Tau Alzheimer’s Pathology in Cognitively Normal Aging (2010, background): “Consistent with this premise, an APOE genotype effect on A plaque load recently has been demonstrated in amyloid imaging studies in individuals with moderate DAT(50) and in nondemented individuals.(51,52) However, because of small sample sizes, these studies did not address the influence of age on t”
• Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012, background): “Cognitively normal apoE4-positive middle-aged and elderly individuals are much more likely to have brain amyloid (Reiman et al. 2009; Morris et al. 2010) and low CSF Ab42 (Sunderland et al. 2004; Morris et al. 2010) than apoE4-negative individuals.”
• Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011, background): “Similarly, genetic at-risk cohorts demonstrate evidence ofAb accumulation many years before detectable cognitive impairment [38–41].”