Mosaic Organization of Neural Stem Cells in the Adult Brain

By Florian Merkle, Z. Mirzadeh, Arturo Alvarez-Buylla. 2007

843 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Seizures increase cell proliferation in both SGZ and SVZ (reviewed by Jessberger and Parent, 2007).”
Adult neurogenesis and the olfactory system. (2009, methodology): “These adult stem cells are derived from radial glia (Merkle et al., 2004; Merkle et al., 2007), which function as neural stem cells during embryonic development (Anthony et al., 2004).”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “Although infusion of FGF2 does not affect SGZ proliferation in young mice, deletion of fgfr1 in the CNS decreases SGZ neurogenesis (Jin et al., 2003; Zhao et al., 2007).”
Adult generation of glutamatergic olfactory bulb interneurons (2009, background): “, this view has recently been challenged by the demonstration that there are distinct NSCs with restricted potential regarding subtype specificatio”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Neural stem cells in the forebrain subventricular zone have been fate mapped using a variety of approaches that have demonstrated regional heterogeneity in the embryonic origin, developmental potential, and fate of these cells (Merkle et al., 2007; Young et al., 2007).”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “For example, ventral NSCs produce deep granule cells and calbindin-expressing periglomerular cells, whereas dorsal NSCs produce superficial granule cells and tyrosine-hydroxylase-expressing periglomerular cells (Merkle et al., 2007).”
Directed differentiation of hippocampal stem/progenitor cells in the adult brain (2008, background): “A recent study suggested that neural stem cells derived from the SVZ show a region-specific diversity that is also maintained on heterotopic transplantatio”
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine SVZ-neuronal progenitors via cell autonomous mechanisms involving Notch signaling (2010, background): “Given the complexity of cell types in the adult SVZ that are in S-phase, it is highly likely that these cells will be labeled following long-term or multidose injection of BrdU (Merkle et al., 2007) that would easily mask small differences between the groups.”
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator (2020, background): “…et al., 2015), generating different olfactory bulb (OB) interneuron subtypes or glia depending on their location (Brill et al., 2009; Delgado and Lim, 2015; Kohwi et al., 2005; López-Juárez et al., 2013; Merkle et al., 2014, 2007; Mizrak et al., 2019; Ortega et al., 2013; Zweifel et al., 2018).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, methodology): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript experiments suggest that this specification is cell-autonomous and not easily modified by homotopic and heterotopic grafting (Kelsch et al. 2007, Merkle et al. 2007, Young et al. 2007).”
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. (2015, positive): “NSCs not only differ in their state of activation, but also distinct pools of NSCs with different capacity to produce neuronal and glial progeny have been proposed to exist in the adult SVZ (Calzolari et al., 2015; Merkle et al., 2007; Ortega et al., 2013; Young et al., 2007).”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, positive): “In another study, adenovirus-mediated Cre expression under the control of the GFAP promoter was used to label a patch of radial glia-like cells in the adult SVZ of the Z/EG reporter mice (Merkle et al., 2007).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “For example, could the region-restricted production of astrocytes help to establish the molecular and functional diversity of this population? In the case of the adult subventricular zone, one study indicates that the dorsal–ventral patterning of type B cells is reflected in permanent restrictions o”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “Since terminal neurons were not profiled by Mikkelsen and colleagues, we can only speculate that cellular heterogeneity of neuronal stem cells, which would dilute cell-type specific targets, might account for this discrepancy (Merkle et al., 2007).”
Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay For Stem Cells (2011, background): “Beige block indicates neurosphere-forming cells in the lineage. regionally specified and that precursors for different interneuron subtypes reside in different regions (Hack et al., 2005; Merkle et al., 2007; Young et al., 2007; Kelsch et al., 2007; Ventura and Goldman, 2007).”