Adult generation of glutamatergic olfactory bulb interneurons

By M. Brill, J. Ninkovic, Eleanor Winpenny, R. Hodge, Ilknur Ozen, Roderick Yang, A. Lepier, S. Gascón, F. Erdélyi, G. Szabó and 7 more. 2009

384 citations recorded by the source corpus.

The adult mouse subependymal zone (SEZ) harbors neural stem cells that are thought to exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult generation of glutamatergic juxtaglomerular neurons, which had dendritic arborizations that projected into adjacent glomeruli, identifying them as short-axon cells. Fate mapping revealed that these originate from Neurog2- and Tbr2-expressing progenitors located in the dorsal region of the SEZ. Examination of the progenitors of these glutamatergic interneurons allowed us to determine the sequential expression of transcription factors in these cells that are thought to be hallmarks of glutamatergic neurogenesis in the developing cerebral cortex and adult hippocampus. Indeed, the molecular specification of these SEZ progenitors allowed for their recruitment into the cerebral cortex after a lesion was induced. Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair.

Subfields: Developmental Neuroscience, Neurology, Sensory Systems

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. M. Götz
2. J. Frisén
3. D. Lagace
4. M. Bergami
5. D. C. Lie
6. Jagroop Dhaliwal
7. Hongjun Song
8. Guo-li Ming

In Neurology

1. M. Götz
2. D. Lagace
3. D. C. Lie
4. Jagroop Dhaliwal

Citations in the corpus

• Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator (2020, neutral): “, 2015), generating different olfactory bulb (OB) interneuron subtypes or glia depending on their location (Brill et al., 2009; Delgado and Lim, 2015; Kohwi et al., 2005; López-Juárez et al., 2013; Merkle et al., 2014, 2007; Mizrak et al., 2019; Ortega et al., 2013; Zweifel et al., 2018).”
• RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “…studies revealed considerable heterogeneity among NSCs from distinct neurogenic regions with regard to their differentiation pattern (Hack et al., 2005; Merkle et al., 2007; Brill et al., 2009) and their proliferative/self-renewal behavior (Seaberg and van der Kooy, 2002; Bull and Bartlett, 2005).”
• Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, neutral): “Distinct populations of periglomerular cells (PGCs) also arise from specific locations within the anterior and medial adult VZ-SVZ, and a population of glutamatergic olfactory bulb neurons is derived from the dorsal SVZ (Merkle et al., 2007; Brill et al., 2009).”
• Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. (2015, neutral): “These subtypes are believed to be derived from distinctly located sets of committed NSCs, and not from a pan-subtype multipotent NSC (Brill et al., 2009; Kelsch et al., 2007; Merkle et al., 2007; Young et al., 2007).”
• Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, methodology): “express Ngn2 in the adult are localized in RMS and DG, but not in the ventral or lateral SVZ (Brill et al., 2009).”
• Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb (2013, background): “There, the neuroblasts migrate radially and differentiate into various types of interneurons populating both the granule cell layer (GCL) and the glomerular layer (17, 18).”