Role of Adiponectin in Preventing Vascular Stenosis

By M. Matsuda, I. Shimomura, M. Sata, Y. Arita, M. Nishida, N. Maeda, M. Kumada, Y. Okamoto, H. Nagaretani, H. Nishizawa and 7 more. Journal of Biological Chemistry, 2002

845 citations recorded by the source corpus.

Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity and vascular disease is still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subjects, and that hypoadiponectinemia is associated to ischemic heart disease. In current the study, we investigated the in vivorole of adiponectin on the neointimal thickening after artery injury using adiponectin-deficient mice and adiponectin-producing adenovirus. Adiponectin-deficient mice showed severe neointimal thickening and increased proliferation of vascular smooth muscle cells in mechanically injured arteries. Adenovirus-mediated supplement of adiponectin attenuated neointimal proliferation. In cultured smooth muscle cells, adiponectin attenuated DNA synthesis induced by growth factors including platelet-derived growth factor, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), basic fibroblast growth factor, and EGF and cell proliferation and migration induced by HB-EGF. In cultured endothelial cells, adiponectin attenuated HB-EGF expression stimulated by tumor necrosis factor α. The current study suggests an adipo-vascular axis, a direct link between fat and artery. A therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/afdca3518820d9fa45485b076f70b5b2b488ba6e

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Citations in the corpus

Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. (2004, background): “Furthermore, neointimal thickening of damaged arteries is exacerbated in adiponectin-deficient mice and is inhibited by exogenous adiponectin (101).”
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Adiponectin Regulation and Function (2018, positive): “In support of this postulated paracrine anti-inflammatory effect of adiponectin on M1 macrophages, adiponectin knock-out mice have increased neointimal thickening and vascular smooth muscle proliferation following vascular injury (204).”
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. (2003, background): “Finally, adiponectin deficiency in knockout mice causes diet-induced insulin resistance and diabetes and increases neointimal thicking in the arterial wall by mechanic injury (20,26,27).”
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction (2017, background): “Experimental studies with cell cultures and animal models have shown cardioprotective action of adiponectin in cell types, including: vascular endothelial cells, smooth muscle cells, and cardiac myocytes and adiponectin-deficient mice [7].”
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The role of the novel adipocyte-derived hormone adiponectin in human disease. (2003, background): “The recent finding that adiponectin deficiency aggravates neointimal thickening, and that supplementation with adiponectin attenuates neointimal thickening in mechanically injured arteries, suggests that increasing plasma adiponectin might be useful in preventing vascular restenosis after vascular i”
Obesity and inflammation: the linking mechanism and the complications (2016, background): “Adiponectin is a protein hormone derived from adipocytes that has gained considerable importance due to its positive impacts on inflammation [99], atherosclerosis, T2DM, and insulin resistance [99–101]; thus, it links the adipose tissue directly with the cornerstones of metabolic abnormalities [102]”