The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

By D. Ruggero, L. Montanaro, Li Ma, W. Xu, P. Londei, C. Cordon-Cardo, P. Pandolfi. Nature Medicine, 2004

620 citations recorded by the source corpus.

Subfields: Cancer Research, Dermatology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/afbef651eab951592e7900d59e8ce9068b3d9560

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. St-Pierre
2. Dean W. Felsher
3. Eyal Gottlieb
4. Nahum Sonenberg
5. Michael Pollak
6. C. V. Dang
7. M. V. Vander Heiden

In Molecular Biology

1. David M. Sabatini
2. C. Fraser
3. Michael Pollak
4. Nahum Sonenberg
5. K. Feoktistova
6. Enkhee Tuvshintogs
7. A. Do
8. J. Testa

Citations in the corpus

• mTOR, translation initiation and cancer (2006, background): “Furthermore, two groups independently demonstrated that eIF4E promotes lymphomagenesis in cooperation with Myc in transgenic mice (Ruggero et al., 2004; Wendel et al., 2004).”
• Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 (2009, background): “mTORC1 integrates signals from growth factor receptors with cellular nutritional status and controls the level of cap-dependent mRNA translation by modulating the activity of key translational components such as the cap-binding protein and oncogene eIF4E [5].”
• Perturbations of the AKT signaling pathway in human cancer (2005, background): “For example, eIF4E has been shown to cooperate with c-Myc in B-cell lymphomagenesis (Ruggero et al., 2004; Wendel et al., 2004).”
• Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity (2013, background): “of immortalized cells and tumor formation in mice (9, 10, 12).”
• MYC as a regulator of ribosome biogenesis and protein synthesis (2010, background): “The increased expression of ribosomal proteins has also been associated with increased proliferation and growt”
• With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, neutral): “Overexpression of eIF4E has also been shown to increase cellular senescence in mammalian cells as determined by b-galactosidase staining (Ruggero et al., 2004).”
• mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. (2013, methodology): “…(Laplante and Sabatini, 2012), and eIF4E overexpression is tumorigenic in vitro and in vivo (Avdulov et al., 2004; LazarisKaratzas et al., 1990; Ruggero et al., 2004; Wendel et al., s described in (A) and treated with asTORi for 12 hr (A) and treated with asTORi for 12 hr. Cells were rmined by…”
• Translational Control in Cancer. (2018, background): “eIF4E and eIF4G act as classical oncogenes, their overexpression resulting in transformation in vitro (in cell culture) and in vivo (in animals) (Lazaris-Karatzas et al. 1990; Fukuchi-Shimogori et al. 1997; Ruggero et al. 2004; Silvera et al. 2009).”