Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity

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Protein Synthesis Initiation in Eukaryotic Cells. (2018, background): “All of these activities are also found in the eIF4F complex where the level of activity is always greater (Abramson et al. 1987; Rozen et al. 1990; Feoktistova et al. 2013; Sokabe and Fraser 2017).”
The scanning mechanism of eukaryotic translation initiation. (2014, background): “Recent research has shown that eIF4E stimulates eIF4A helicase activity by its interaction with eIF4G, which appears to overcome an autoinhibitory activity in eIF4G (123).”
Translational Control in Cancer. (2018, background): “The enzymatic component, eIF4A, provides the helicase activity required to unwind secondary structures present in mRNA 50 untranslated regions (UTRs), a process that is vastly enhanced by binding to eIF4G and eIF4E (Feoktistova et al. 2013).”