The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

By Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Hui-zhen Wang and 2 more. Nature Medicine, 2011

1,154 citations recorded by the source corpus.

Subfields: Cancer Research, Electrical and Electronic Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/916b625147e3345797e42bd6882fa4e69acbbd3c

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In Cancer Research

1. E. Olson
2. Xing Chen
3. Zhuhong You
4. Di Xie
5. Qi Zhao
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In Molecular Biology

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Citations in the corpus

• Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver (2007, neutral): “For example, a mutation in the target site of miR-189 in the human SLITRK1 gene was shown to be associated with Tourette’s syndrome (7), while other recent studies have implicated miRNAs in controlling HIV replication (8) and in coronary artery disease (9).”
• Non-coding RNAs in human disease (2011, background): “This miRNA has been linked with the development of arrhythmias as it downregulates expression of the ion channel gene”
• Altered microRNA expression in human heart disease. (2007, background): “We found that miR-1 was downregulated in ICM, while Yang and colleagues (22) recently reported it was upregulated in ICM.”
• MicroRNAs in development and disease. (2011, background): “miR-1 is increased in the human hearts that have suffered coronary artery disease (CAD) and in rat ischemic hearts, which are associated with an increase in arrhythmogenesis (686).”
• Expression of microRNA-146 in rheumatoid arthritis synovial tissue. (2008, background): “Evidence of microRNA function in conditions such as leukemia, viral infection, and DiGeorge syndrome has been reported (24–29), and therapeutic trials aimed at silencing microRNA in vivo have been conducted (29,30).”
• A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits (2009, background): “Recently, it was reported that a muscle-specific microRNA regulates cardiac arrhythmogenic potential by targeting GJA1 (ref”
• miR2Disease: a manually curated database for microRNA deregulation in human disease (2008, background): “(29) found that miR-1 overexpression slowed cardiac conduction and depolarized the cytoplasmic membrane by post-transcriptionally repressing KCNJ2 and GJA1, which accounted at least in part for its arrhythmogenic potential.”
• MicroRNAs and complex diseases: from experimental results to computational models (2019, positive): “Furthermore, mir-375 can regulate insulin secretion [110]; the miR-1 is involved in heart development; deletion of miRNA-1-2 interrupts the regulation of carcinogenesis [111, 112].”