IL-1 is required for tumor invasiveness and angiogenesis

By E. Voronov, D. Shouval, Y. Krelin, E. Cagnano, D. Benharroch, Y. Iwakura, C. A. Dinarello, R. Apte. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,045 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/adee010b506385915a7fe111a1e50590ab02e189

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Mantovani
2. J. Tschopp
3. M. Karin
4. A. Sica
5. Fabio Martinon
6. P. Allavena
7. F. Greten
8. J. Pollard

In Oncology

1. A. Mantovani
2. M. Karin
3. A. Sica
4. J. Pollard
5. P. Allavena
6. S. Ostrand-Rosenberg
7. C. Garlanda
8. F. Greten

Citations in the corpus

• Inflammatory caspases and inflammasomes: master switches of inflammation (2007, background): “tumor angiogenesis and invasiveness of different tumor cells in mice.(24,25) Moreover, IL-1b plays a role in destructive joint and bone diseases.”
• Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Consistent with the down-regulation of antitumor immunity by MDSC, IL-1 -secreting tumors were more invasive and progressed more rapidly than non-IL-1 -producing tumors (80, 83).”
• IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis (2003, background): “Recent in vivo studies demonstrating that host-derived IL-1β is critical for tumor growth, angiogenesis, and invasiveness (9, 11) should be revisited in light of the IL-1–HIF-1–VEGF connection.”
• Tumour-educated macrophages promote tumour progression and metastasis (2004, background): “IL-1 is synthesized by macrophages and, in these experiments, IL-1β was required for tumour-cell invasiveness and angiogenesi”
• NF-κB: linking inflammation and immunity to cancer development and progression (2005, background): “IL-1 is also required for the in vivo angiogenesis and invasiveness of different tumour cell”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “as IL-1β, IL-6 and TNF-α [11-14].”
• Cytokines in cancer pathogenesis and cancer therapy (2004, background): “Il-1 was required for the invasion and angiogenesis associated with transplantable tumour”