The cancer stem cell: premises, promises and challenges

By Hans Clevers. Nature Medicine, 2011

1,901 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5a7f25dc63acc337977d4119d67da87d5099900b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. V. Plaks
2. Zena Werb
3. Niwen Kong
4. J. Massagué
5. V. Silva-Vargas
6. Érika Pastrana
7. J. Dick
8. F. Doetsch

In Molecular Biology

1. E. Batlle
2. V. Plaks
3. Zena Werb
4. J. Massagué
5. Thordur Oskarsson
6. V. Silva-Vargas
7. Érika Pastrana
8. J. Dick

In Oncology

1. Zena Werb
2. V. Plaks
3. Niwen Kong
4. J. Massagué
5. Antonija Krešo
6. E. Batlle
7. Thordur Oskarsson
8. V. Silva-Vargas

Citations in the corpus

• 3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs (2018, result): “…the last years, the results obtained show the presence of a subpopulation of cancer cells with stem cell‐like properties—CSC—in the mass of different tumors, such as breast, brain, colon, gastric, hepatic, lung, ovarian, pancreas, prostate, and skin cancers (Clevers, 2011; S. Franco et al., 2016).”
• Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “Indeed, xenograft serial transplantation studies involving several tumor types lend support to this model, although the applicability of these findings to all types of human malignancies continues to be debated (Shackleton et al., 2009; Clevers, 2011).”
• Evolution of the cancer stem cell model. (2014, background): “As we have argued throughout this Review, both genetic and nongenetic determinants influence tumor heterogeneity and often these two views have been presented as mutually exclusive models, stimulating intense debate (Clevers, 2011 et al., 2012; Shackleton et al., 2009).”
• Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay For Stem Cells (2011, methodology): “Sphere-forming assays are increasingly used, both retrospectively and prospectively, to investigate stem cells and progenitors in many tissues during development and in the adult (Table 2), as well as in cancers and the cancer stem cell field (Hirschhaeuser et al., 2010; Clevers, 2011).”
• Metastatic Stem Cells: Sources, Niches, and Vital Pathways (2014, background): “Quantitative lineage tracing clonal analysis is needed to assess the abundance of CSCs in different tumor types (Clevers, 2011; Meacham and Morrison, 2013; Beck and Blanpain, 2013).”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “Moreover, many of these markers, especially in solid tumors, fail to distinguish normal stem cells from CSCs. High-throughput screening could be an unbiased approach to uncover known or new compounds that specifically target CSCs (Clevers, 2011).”
• Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 (2018, background): “Emerging evidence indicates that cancer stem cells (CSCs), a cellular subpopulation with stem cell-like features, are critical for CRC initiation, progression, relapse, metastasis and chemoresistance [3-5].”