The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells

By Qin Shen, Yue Wang, J. Dimos, Christopher A. Fasano, T. Phoenix, Ihor R. Lemischka, N. Ivanova, S. Stifani, E. Morrisey, Sally Temple. Nature Neuroscience, 2006

641 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad789b8b4b572083edc5c0da0567a598a32fbb84

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Mechanisms of stem cell self-renewal. (2009, background): “For example, Drosophila neuroblasts and mammalian cortical and retinal neural stem cells undergo temporal restrictions in the types of neurons they can make during development (Desai & McConnell 2000, Livesey & Cepko 2001, Pearson & Doe 2003, Shen et al. 2006).”
Development and Evolution of the Human Neocortex (2011, positive): “However, this is not a rule, as neural progenitor cells isolated in culture recapitulate the proper timing and sequence of neuron production (Shen et al., 2006).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “This developmental program is largely cell-intrinsic, because cultured neural progenitors derived from the embryonic CNS, as well as embryonic-stem-cell-derived neural progenitors, generate neuron subtypes in a precise temporal and laminar orde”
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. (2008, background): “These observations are in accordance with the intrinsic temporal program of cortical neurogenesis shown with cortical progenitors derived from the embryonic brain ( Shen et al., 2006 ) and, very recently, with those from ESCs (Gaspard et al., 2008).”
Late-Stage Neuronal Progenitors in the Retina Are Radial Müller Glia That Function as Retinal Stem Cells (2007, background): “, 2003) and cerebral cortex (Shen et al., 2006) and grown in defined medium in cell culture revealed highly regular cell lineages that astonishingly parallel the exact timing and order of histogenesis seen in vivo.”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Additionally, individual neurogenic progenitor cells can contribute neurons to multiple layers (Luskin et al. 1988), and even in isolated cell cultures, NSCs can generate neurons in a precise temporal and laminar order, echoing the in vivo sequence (Shen et al. 2006).”
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex (2013, background): “These findings indicate a biased tendency in the localization of neurons reminiscent of the inside-out pattern during fetal corticogenesis (5, 6), in which late-born CP neurons are located outside and early-born CP neurons are inside.”
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses (2012, background): “Primary mouse cortical stem and progenitor cells generate projection neurons when grown at clonal density in vitro , although they produce many fewer upper layer, late-born neurons in vitro than they do in vivo”
Neuronal subtype specification in the cerebral cortex (2007, background): “, these data suggest that the timing and progression to produce a given subtype of projection neuron is at least partially intrinsic to progenitor”