Development and Evolution of the Human Neocortex

By Jan H. Lui, David V. Hansen, A. Kriegstein. Cell, 2011

1,269 citations recorded by the source corpus.

The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium. We discuss how proliferation of cells within the OSVZ expands the neocortex by increasing neuron number and modifying the trajectory of migrating neurons. Relating these features to other mammalian species and known molecular regulators of the mouse neocortex suggests how this developmental process could have emerged in evolution.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/962870c5dba05965a93dabde5426ac6cb66dec5f

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Citations in the corpus

Brain organoids: advances, applications and challenges (2019, background): “Immediately adjacent to the VZ, a thin and dense layer of TBR2 (EOMES) intermediate progenitor cells (IPCs) can be found, resembling the iSVZ (Lui et al., 2011).”
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016, positive): “…progenitor cells of the VZ transition into another form of neural stem or progenitor cell, called radial glia (RG), which extend a very long process to the pial surface of the expanding neocortical wall (Bystron et al., 2006; Howard et al., 2008; Lui et al., 2011; Taverna et al., 2014).”
The cell biology of neurogenesis: toward an understanding of the development and evolution of the neocortex. (2014, background): “This part of the brain shows the greater extent of phylogenetic expansion, which occurs during its ontogeny (Borrell & Reillo 2012, Kriegstein et al. 2006, Lui et al. 2011).”
Brain Region-specific Organoids using Mini-bioreactors for Modeling ZIKV Exposure (2016, positive): “One hallmark of embryonic human cerebral cortex is the prominence of specialized oRGCs in the oSVZ layer (Lui et al., 2011).”
A developmental and genetic classification for malformations of cortical development: update 2012 (2012, background): “Early cortical progenitors are competent to generate late-born neurons after transplantation into older hosts, indicating that they can respond to later environmental cues, but progenitors become progressively restricted in their ability to populate different lamina as neurogenesis proceeds (Lui et ”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “Due to its intricacy, the nervous system (NS) represents one of the most important biological systems and is comprised of different cell types and advanced synaptic communications [250].”
Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size (2014, result): “Based on the same assumption, other studies (Finlay and Darlington, 1995; Rakic, 1995; Lui et al., 2011; Charvet et al., 2013) have concentrated on explaining how increased numbers of neurons in the developing cerebral cortex would result in cortical expansion across rodents, artiodactyls and…”
Neural progenitors, neurogenesis and the evolution of the neocortex (2014, background): “2B), hence allowing migrating neurons to D E V E LO P M E N T spread in the lateral dimension (Lui et al., 2011; Reillo et al., 2011; Borrell and Reillo, 2012; Reillo and Borrell, 2012; Kelava et al., 2013; Lewitus et al., 2013).”