Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

By Mototsugu Eiraku, Kiichi Watanabe, M. Matsuo‐Takasaki, Masako Kawada, S. Yonemura, Michiru Matsumura, T. Wataya, Ayaka Nishiyama, K. Muguruma, Y. Sasai. Cell Stem Cell, 2008

1,394 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/5379fe96e4803f7f975da3d76a84a920cc95d602

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Hans Clevers
2. Juergen A. Knoblich
3. Madeline A. Lancaster
4. Robert Langer
5. Ali Khademhosseini
6. V. Mohanraj
7. Y. Chen

In Cellular and Molecular Neuroscience

1. Hans Clevers
2. Hongjun Song
3. Juergen A. Knoblich
4. Guo-li Ming
5. Madeline A. Lancaster
6. Robert Langer
7. Xuyu Qian
8. A. Kriegstein

In Cognitive Neuroscience

1. Hans Clevers
2. Hongjun Song
3. Guo-li Ming
4. A. Kriegstein

Citations in the corpus

• Self-formation of optic cups and storable stratified neural retina from human ESCs. (2012, methodology): “, 2011) using a versatile floating culture in serum-free and growth-factor-reduced medium (SFEBq culture, or serum-free culture of embryoid body-like aggregates with quick aggregation; Wataya et al., 2008; Eiraku et al., 2008).”
• Stem Cell Organoid Engineering (2016, positive): “…(serumfree floating culture of embryoid body-like aggregates with quick re-aggregation) protocol has been used to generate the more complex architectures, such as sub-brain regions like the cerebral cortex (Danjo et al., 2011; Eiraku et al., 2008; Kadoshima et al., 2013; Mariani et Cell Stem Cell.”
• Developmental genetics of vertebrate glial–cell specification (2010, background): “This developmental program is largely cell-intrinsic, because cultured neural progenitors derived from the embryonic CNS, as well as embryonic-stem-cell-derived neural progenitors, generate neuron subtypes in a precise temporal and laminar orde”
• Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3 (2016, positive): “Several groups have developed cerebral organoidmodels that generate functional cortical neurons and can recapitulate forebrain, midbrain, and hindbrain regions with functional electrophysiological properties to probe the mechanisms of neurodevelopment, autism, and microcephaly (Camp et al., 2015; Ei”
• Organogenesis in a dish: Modeling development and disease using organoid technologies (2014, methodology): “Sasai and colleagues generate 3D cerebral cortex tissue from pluripotent stem cells using the SFEBq method (54).”