Signaling pathways in intestinal development and cancer.

By E. Sancho, E. Batlle, Hans Clevers. Annual Review of Cell and Developmental Biology, 2004

587 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad3c791e02967a528009b8395bd2f5839d801878

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. A. Gregorieff
3. Linheng Li
4. T. Xie
5. D. Alessi
6. Nick Barker
7. Guo-li Ming
8. Hongjun Song

In Molecular Biology

1. Hans Clevers
2. Linheng Li
3. A. Gregorieff
4. James M. Wells
5. Aaron M. Zorn
6. T. Xie
7. D. Alessi
8. Pengfei Lu

Citations in the corpus

• Hypoxia-inducible factors in stem cells and cancer (2009, unknown): “In mammals, stem cell niches have been described in multiple tissues, including the gonad [23], skin [24–26], intestine [27], bone marrow (BM) [28, 29] and brain [30, 31].”
• Epithelial stem cells: turning over new leaves. (2007, unknown): “Mutations that affect BMP signaling account for almost half of the cases of juvenile polyposis syndrome, a condition that can lead to intestinal cancer (Sancho et al., 2004).”
• Vertebrate Endoderm Development and Organ Formation (2009, background): “The adult GI tract is a three-layered tube, with an endoderm epithelial mucosa lining the lumen surrounded by connective mesenchyme and smooth muscle, which is innervated by neural crest-derived enteric neurons that control peristalsis (Rubin 2007, Sancho et al. 2004).”
• Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis (2005, background): “In many forms of human colorectal cancer, mutations arise, mainly in APC and b-catenin, that induce the stabilisation of b-catenin, causing uncontrolled activation of the pathway, which leads to loss of cell polarity and increased proliferation (Sancho et al, 2004).”
• Stem cell niche: structure and function. (2005, background): “…generally proposed to be located at the fourth or fifth position from the crypt bottom, above the Paneth cells (Booth & Potten 2000, He et al. 2004, Sancho et al. 2004), as evidenced either through a DNA-labeling retaining assay (Booth & Potten 2000, He et al. 2004, Potten et al. 1997, 2002) or…”
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, background): “…cell divisions in the crypts of Lieberkühn, promoted by WNT signaling, drive gut epithelial renewal in a ‘‘conveyor-belt’’ fashion, generating a constant supply of differentiated cells to the villi, where they are autonomously exfoliated (Gregorieff and Clevers, 2005; Sancho et al., 2004).”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “TGF signaling components are localized in differentiated epithelial cells, where they have well-documented growth suppressive effects (Sancho et al. 2004).”
• Insulin signaling promotes germline proliferation in C. elegans (2010, background): “The intersection of cell proliferation and cell fate specification is important for understanding human diseases, particularly cancer, which is characterized by the dysregulation of both proliferation and fate (see Hanahan and Weinberg, 2000; Sancho et al., 2004).”