Wound healing and its impairment in the diabetic foot.

By V. Falanga. The Lancet, 2005

2,314 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Occupational Therapy, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/acb71a1a30a2dc4728ac3ec0043274c0c9a7b65c

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In Endocrinology, Diabetes and Metabolism

In Occupational Therapy

In Rehabilitation

Citations in the corpus

Inflammation in Chronic Wounds (2016, background): “A pathogenic triad of neuropathy, ischaemia, and trauma is traditionally described [24].”
Challenges in the Treatment of Chronic Wounds (2015, background): “During this phase, the provisional matrix is remodeled into organized collagen bundles.(14,15)”
Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing (2008, background): “Many growth factors such as PDGF and VEGF have been known to be crucial for the recruitment, survival and proliferation of these cells and subsequent neovascularization [2,3].”
Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits (2017, background): “Apart from the infection, symptoms such as pain, swelling, and redness might not be present for diabetic peripheral neuropathy patients due to their reduced immune response, which further complicates the diagnosis [46].”
Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings. (2008, background): “The risk for lower extremity arterial ulceration is increased in smokers, diabetics, elderly patients, and individuals with evidence of arterial disease at other sites.(30,31) Arterial insufficiency often causes symptoms of intermittent”
Pathogenetic mechanisms in radiation fibrosis. (2010, background): “In surgical scarring, myofibroblasts and inflammatory cells eventually undergo apoptosis to leave hypocellular scar tissue [10,11].”
The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes (2018, background): “During remodeling, the final phase of wound healing, ECM within the granulation tissue matures and increases in mechanical strength (Falanga, 2005).”
Polymicrobial Interactions: Impact on Pathogenesis and Human Disease (2012, background): “broblast migration, and macrophage function (59, 65, 66, 130).”
Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. (2018, background): “Wound healing is a complicated process including four overlapping phases: coagulation, inflammation, migration-proliferation (including matrix deposition), and remodeling (Falanga, 2005; Kirsner & Eaglstein, 1993; Velnar et al., 2009).”
Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care (2012, background): “Other abnormalities leading to development of chronic wounds in diabetic patients (also called diabetic ulcers) include neuropathy, often linked to vascular impairment, deficiencies in muscle metabolism, and a number of microvascular pathologies often caused by hyperglycemia.(4) Macroscopic patholog”
Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights (2014, background): “In diabetic neuropathy the nerve axon-related vasodilation (Lewis tripleflare response) is reduced or even absent [7].”
In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, neutral): “These effects induce the transformation of many acute wounds into painful chronic ulcers which may take months or years to heal causing significantly reduced quality of life and potentially resulting in amputation if ignored or improperly treated [22].”
Research Techniques Made Simple: Analysis of Collective Cell Migration Using the Wound Healing Assay. (2017, background): “In smaller wounds, the critical event is keratinocyte migration rather than proliferation (Falanga, 2005).”