In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair

By R. Dimatteo, N. Darling, T. Segura. Advanced Drug Delivery Reviews, 2018

738 citations recorded by the source corpus.

&NA; Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. Initially, these materials were formed outside of the patient and implanted using invasive surgical techniques. However, advances in synthetic chemistry and materials science have now provided researchers with a library of techniques whereby hydrogel formation can occur in situ upon delivery through standard needles. This provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body. In this review, we highlight these injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair. Graphical abstract Figure. No caption available.

Subfields: Biomaterials, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/ab65552445da468ca93a49e47fc9fcc9a8a9c3fe

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Citations in the corpus

• Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications (2020, background): “The first reported hydrogel can be traced back to 1960, when Wichterle and Lim synthesized poly (2-hydroxethyl methacrylate) (PHEMA) and utilized it in the contact lens industry with the ability of imbibing moisture while asserting its network structure, demonstrating the modern hydrogel [1,2].”