Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care
By Tatiana N. Demidova-Rice, Michael R Hamblin, I. Herman. Advances in Skin & Wound Care, 2012
648 citations recorded by the source corpus.
This is the first installment of 2 articles that discuss the biology and pathophysiology of wound healing, review the role that growth factors play in this process, and describe current ways of growth factor delivery into the wound bed. Part 1 discusses the latest advances in clinicians’ understanding of the control points that regulate wound healing. Importantly, biological similarities and differences between acute and chronic wounds are considered, including the signaling pathways that initiate cellular and tissue responses after injury, which may be impeded during chronic wound healing.
Subfields: Endocrinology, Diabetes and Metabolism, Occupational Therapy, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/8bdaee4e3240342d6aff43159af3b18d7c6e0d57
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Citations in the corpus
- Drug Delivery Systems and Materials for Wound Healing Applications (2018, neutral): “Chronic wounds are often characterized by the presence of high quantities of necrotic tissue which limits healing and is the ideal pabulum for bacterial colonization and growth [8].”
- Inflammation in Chronic Wounds (2016, background): “In response to mechanical tension and cytokines such as TGF-β, fibroblasts increase expression of α-smooth muscle actin, transforming into myofibroblasts, which contract the wound via their integrin receptor contacts to ECM components such as fibronectin and collagen [32,36].”