Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors
By Vincent Breton-Provencher, M. Lemasson, Modesto R. Peralta, Armen Saghatelyan. 2009
260 citations recorded by the source corpus.
Olfactory bulb (OB) interneurons are continuously renewed throughout an animal's lifespan. Despite extensive investigation of this phenomenon, little is known about bulbar circuitry functioning and olfactory performances under conditions of ablated arrival of new neurons into the adult OB. To address this issue we performed morphological, electrophysiological, and behavioral analysis in mice with suppressed bulbar neurogenesis. Infusion of the antimitotic drug AraC to the lateral ventricle via 28 d osmotic minipumps abolished the arrival of newly born neurons into the adult OB without affecting the total number of granule cells. The number, dendritic arborization, and spine density of interneurons generated in adulthood, before pump installation, were also not affected by AraC treatment. As a result of ablated neurogenesis, mitral cells—the principal output neurons in the OB—receive fewer inhibitory synapses, display reduced frequency of spontaneous IPSCs, experience smaller dendrodendritic inhibition, and exhibit decreased synchronized activity. Consequently, short-term olfactory memory was drastically reduced in AraC-treated mice. In contrast, olfactory performances of AraC-treated animals were undistinguishable from those of control mice in other odor-associated tests, such as spontaneous odor discrimination and long-term odor-associative memory tasks. Altogether, our data highlight the importance of adult neurogenesis for the proper functioning of the OB network and imply that new bulbar interneurons are involved in some, but not all, odor-associated tasks.
Subfields: Developmental Neuroscience, Neurology, Sensory Systems
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Citations in the corpus
- Adult-born neurons facilitate olfactory bulb pattern separation during task engagement (2018, unknown): “However, other studies have found little effects of ABN manipulation on odor discrimination (Breton-Provencher et al., 2009; Imayoshi et al., 2008; Lazarini et al., 2009).”
- Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal Behavior (2010, unknown): “Frontiers in Behavioral Neuroscience www.frontiersin.org December 2010 | Volume 4 | Article 176 | 11 with ablated neurogenesis (Breton-Provencher et al., 2009).”
- Is adult neurogenesis essential for olfaction? (2011, unknown): “Thus, the contribution of adult-generated neurons to bulbar physiology remains unclear and conflicting results have been reported regarding the functional outcomes of adult neurogenesis for olfaction [73-75].”
- Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, unknown): “Reduced olfactory bulb neurogenesis disrupts normal synaptic inhibition and stimulus evoked gamma frequency oscillations (Breton-Provencher et al., 2009), which should impair odor-evoked activity patterns.”
- A Critical Time Window for the Recruitment of Bulbar Newborn Neurons by Olfactory Discrimination Learning (2011, background): “showing that a 3 week AraC treatment is associated with an alteration of short-term memory (Breton-Provencher et al., 2009).”