Pattern separation: a common function for new neurons in hippocampus and olfactory bulb

By Amar Sahay, D. Wilson, R. Hen. 2011

551 citations recorded by the source corpus.

While adult born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information.

Subfields: Cognitive Neuroscience, Developmental Neuroscience, Sensory Systems

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Because of limitations of tools that can be applied to humans, there is still ongoing debate about the existence of adult SVZ neurogenesis and a prominent RMS of new neurons in humans (Curtis et al., 2007; Sanai et al., 2004; Wang et al., 2011).”
Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Adult-born granule cells have also been implicated in contextual discrimination (Sahay et al., 2011; Nakashiba et al., 2012; Danielson et al., 2016), a result that parallels recent findings that suggest that adult neurogenesis facilitates pattern decorrelation in the olfactory bulb (Li et al.”
Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb (2012, background): “Such a contribution of neurogenesis to pattern separation has been proposed for the olfactory bulb as well as the dentate gyrus [35].”
Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding (2016, unknown): “Hypotheses attempting to explain the role of abGCs range from modulating the activity of mature GCs (mGCs) through interactions with local interneurons, to themselves providing the DG’s principal output signals (Piatti et al., 2013; Sahay et al., 2011b).”
Environmental enrichment and neurogenesis: from mice to humans (2015, background): “Behaviorally, pattern separation is thought to be a critical component of episodic memory, allowing the encoding of similar experiences as distinct events, without interference [49,50 ].”
Low excitatory innervation balances high intrinsic excitability of immature dentate neurons (2016, background): “pairs per group: factor cell age, F(1,16)1⁄4 16.”
Slow-Wave Sleep-Imposed Replay Modulates Both Strength and Precision of Memory (2014, background): “Storing memories of familiar odorevoked patterns can promote both perceptual stability through pattern completion, and enhance odor discriminability between highly overlapping inputs (pattern separation; Sahay et al., 2011; Wilson and Sullivan, 2011).”
Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network (2012, unknown): “These intrinsic physiological differences contribute to increased excitability and plasticity, which have been suggested to be critical features in theoretical considerations of neurogenesis function (13, 14).”
Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis (2014, background): “These data may also be related to the recent hypothesis that young adult-born neurons modulate 196 Neuron 83, 189–201, July 2, 2014 ª2014 Elsevier Inc. the activity of the entire DG, which in turn impacts CA3 (Sahay et al., 2011a; Lace- field et al., 2012).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, background): “…undergo adult neurogenesis in the brain and new-born GCs are considered to play a key role in learning and memory (Appleby, Kempermann, & Wiskott, 2011; Clelland et al., 2009; Sahay et al., 2011a) processes, including pattern separation (Kesner & Rolls, 2015; van Praag, Kempermann, & Gage, 1999).”