Is adult neurogenesis essential for olfaction?
By F. Lazarini, Pierre Marie Lledo. 2011
286 citations recorded by the source corpus.
In mammals, new neurons are recruited into restricted brain areas throughout life. Adult-born neurons produced in the subventricular zone of the lateral ventricle migrate rostrally towards the olfactory bulb. Although thousands of neurons reach this central structure every day, the functional impact of their integration into mature circuits remains a matter of debate. Recent investigations have revealed no striking sensory deficits per se when adult bulbar neurogenesis is challenged. However, some cognitive functions, such as perceptual learning and olfactory memory, are clearly impaired. In this review we highlight the role of network activity in shaping ongoing neurogenesis and, in turn, how the integration of adult-born neurons refines pre-existing network function, and consequently olfactory behavior.
Subfields: Cell Biology, Developmental Neuroscience, Sensory Systems
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Citations in the corpus
- Inhibitory circuits of the mammalian main olfactory bulb. (2017, background): “While not explicitly addressed in this review, GCs (and particularly adult-born GCs) are likely to play a critical role in MOB plasticity and learning (Lazarini and Lledo 2011; Lepousez et al. 2013).”
- Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb (2012, unknown): “processing is only poorly understood [13,14].”
- Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, unknown): “…are two populations of adult generated interneurons in the olfactory bulb, juxtaglomerular neurons (periglomerular and short axon cells) and inhibitory granule cells (Lazarini and Lledo, 2011), that contribute to lateral inhibition and the spatiotemporal structure of olfactory bulb output activity.”