Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

By K. Palikaras, E. Lionaki, Nektarios Tavernarakis. Nature, 2015

695 citations recorded by the source corpus.

Subfields: Aging, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ac93583ba97dec5f5f41270711259b632782176e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Guido Kroemer
2. Toren Finkel

In Epidemiology

1. L. Galluzzi
2. Guido Kroemer
3. Frank Madeo
4. Huakan Zhao
5. Wen Chen
6. Yongsheng Li
7. C. López‐Otín
8. R. Youle

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Huakan Zhao
4. Wen Chen
5. Yongsheng Li
6. R. Youle
7. Frank Madeo
8. C. López‐Otín

Citations in the corpus

• Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “12,141 Whereas activating mitochondrial autophagy is linked to improved mitochondrial functionality and increased lifespan in mice and C. elegans .”
• The Mitochondrial Basis of Aging (2016, background): “Expression of a predicted Nix homolog, PINK1, and Parkin in C. elegans appears to promote longevity (Palikaras et al., 2015).”
• Metabolic Control of Longevity. (2016, background): “The predominant link between mitochondria and longevity may consist in the acceleration of mitochondrial turnover, implying a combination of increased synthesis (Finley et al., 2012) and mitophagic degradation (Palikaras et al., 2015), globally assuring optimal quality control.”
• Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism (2016, background): “elegans homolog of mammalian BNIP3 and BNIP3L/NIX, key mediators of mitophagy [122, 123], for review see [124].”
• Molecular mechanisms and physiological functions of mitophagy (2021, neutral): “In C. elegans , disruption of mitophagy contributes to progressive accumulation of damaged mitochondria and decreased cellular functions during aging (Palikaras et al , 2015).”
• Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, neutral): “…clear association between increased longevity and constitutive autophagy, which may be mediated through multiple different but over-lapping mechanisms, including nutrient restriction (Hansen et al., 2008), altered mitosis (Ghavidel et al., 2015) and mitochondrial turnover (Palikaras et al., 2015).”
• Molecular definitions of autophagy and related processes (2017, neutral): “In C. elegans , macroau-tophagic responses specific for mitochondria are coordinated with mitochondrial biogenesis owing to the coordinated activity of the BNIP3 homologue DCT-1 and the transcription factor SNK-1 (Palikaras et al , 2015).”
• Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms (2017, background): “Moreover, autophagic flux was apparently impeded by reduced substrate clearance (accumulation of LC3-II and p62 in autolysosomes).”