The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

By Marie Gottar, V. Gobert, T. Michel, M. Belvin, G. Duyk, J. Hoffmann, D. Ferrandon, J. Royet. Nature, 2002

700 citations recorded by the source corpus.

Subfields: Immunology, Insect Science, Microbiology

View Paper: https://www.semanticscholar.org/paper/ab8b06633f09532b8e9a245be4405879230021b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Hoffmann
2. B. Lemaître
3. Frederick M. Ausubel
4. J. Imler
5. C. Hétru
6. S. Gordon
7. Gerald M. Rubin
8. Catherine Dostert

In Insect Science

1. J. Hoffmann
2. B. Lemaître
3. Frederick M. Ausubel
4. J. Imler
5. C. Hétru
6. Gerald M. Rubin
7. Shizuo Akira
8. M. J. Lehane

In Microbiology

1. Frederick M. Ausubel
2. B. Lemaître
3. C. Hétru
4. J. Imler
5. S. Gordon
6. J. Hoffmann
7. Cyril Zipfel
8. Shizuo Akira

Citations in the corpus

• The Toll and Imd pathways are the major regulators of the immune response in Drosophila (2002, background): “Recently, three independent studies have shown that a putative transmembrane protein, PGRP-LC acts upstream of Imd and probably functions in sensing microbial infection (Choe et al., 2002; Gottar et al., 2002; RaÈmet et al., 2002b).”
• Are innate immune signaling pathways in plants and animals conserved? (2005, background): “, whereas a second immune signaling pathway, the immune-deficient mutant (Imd) pathway, responds to Gram-negative bacteria via a peptidoglycan-recognition protei”
• The host defense of Drosophila melanogaster. (2007, background): “Epistatic and phenotypic analyses indicated that PGRP-LC is the major receptor of the Imd pathway (59).”
• The biology of blood-sucking in insects (2005, neutral): “It is already known that the family of peptidoglycan recognition proteins (PGRPs) are insect PRR (Choe et al., 2002; Gottar et al., 2002; Kurata, 2004; Michel et al., 2001; Ramet et al., 2002b).”
• The immune response of Drosophila (2003, background): “Activation of the Imd pathway requires a putative transmembrane protein that is also a member of the PGRP family (PGRP-LC”
• Pattern recognition receptors: doubling up for the innate immune response. (2002, background): “This has become a loose term to cover a wide range of structurally unrelated membrane molecules expressed sophila and higher species (see Gottar et al., 2002, for by macrophages and selected endothelia with broad example).”
• The Drosophila immune system detects bacteria through specific peptidoglycan recognition (2003, background): “PGRP-LC, a putative transmembrane protein, acts upstream of the Imd pathwa”
• Trade‐offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFκB signaling (2006, background): “Although molecules involved in innate immunity protect against life-threatening infections, there is evidence that early or repeated episodes of acute infection may increase mortality and morbidity at older ages in humans ( Finch & Crimmins, 2004 ).”
• The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila (2005, methodology): “Infections by bacteria and fungi were done as describe”
• Pathogen recognition and innate immunity. (2006, neutral): “a member of the PGRP family containing a transmembrane domain have been identified as a PRR in the Imd pathway (Gottar et al., 2002).”