The Drosophila immune system detects bacteria through specific peptidoglycan recognition

By F. Leulier, C. Parquet, S. Pili-Floury, Ji-Hwan Ryu, M. Caroff, W. Lee, D. Mengin-Lecreulx, B. Lemaître. Nature Immunology, 2003

610 citations recorded by the source corpus.

Subfields: Immunology, Insect Science, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/45fc7b41fddecf1284f71da7cc163251dda23c5a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. G. Núñez
2. J. Hoffmann
3. B. Lemaître
4. N. Inohara
5. N. Moran
6. Philipp Engel
7. Shizuo Akira
8. J. Imler

In Insect Science

1. J. Hoffmann
2. Philipp Engel
3. N. Moran
4. B. Lemaître
5. J. Imler
6. C. Hétru
7. Jon S. Miller
8. D. Stanley

In Public Health, Environmental and Occupational Health

1. G. Núñez
2. J. Hoffmann

Citations in the corpus

• The immune response of Drosophila (2003, background): “Gram-positive lysine-peptidoglycan has recently been shown to activate the Toll pathway in a PGRP-SA (Semmelweis)-dependent manner, whereas Gram-negative diaminopimelic acid peptidoglycan induces the Imd pathway through PGRP-L”
• The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections (2007, background): “Consequently, the main microbial inducers that have been identified to date are various forms of peptidoglycans and glucan”
• The host defense of Drosophila melanogaster. (2007, background): “Gram-negative cell envelope, has no effect on Toll and Imd pathway activity, and previous positive results were explained by the presence of PGN contaminants in commercial LPS preparations (108, 109).”
• The gut microbiota of insects - diversity in structure and function. (2013, background): “Activation occurs by binding of different variants of bacterial PGN to extra- or intracellular epithelial receptors belonging to the peptidoglycan recognition protein (PGRP) family (Leulier et al., 2003; Kaneko & Silverman, 2005).”
• Eicosanoid actions in insect cellular immune functions (2006, background): “In our working model of eicosanoid action in insect cellular immunity (Figure 6), circulating hemocytes recognize an immune challenge, most likely by recognition of specific cell components (Leulier et al., 2003).”
• An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid (2003, background): “Recent studies have shown that the Drosophila immune system detects Gram-positive and Gram-negative bacteria through specific recognition of PG”