Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro.

By L. Gabay, S. Lowell, L. Rubin, David J. Anderson. 2003

326 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, unknown): “Studies on cell reprogramming have indicated that lineage-restricted neural progenitors, after exposure to growth factors, can display acquired properties that are not evident in vivo (Gabay et al., 2003; Kondo and Raff, 2000; Palmer et al., 1999).”
Specification of motoneurons from human embryonic stem cells (2005, background): “Similarly, prolonged exposure of mouse neural progenitor cells to FGF2 disturbed regulation of normal dorsoventral identit”
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain (2006, background): “However, neurospheres are exposed to growth factors, which may modify the normal differentiation program of neural progenitors (Doetsch et al., 2002; Gabay et al., 2003; Santa-Olalla et al., 2003; Hack et al., 2004; Reynolds and Rietze, 2005 In contrast, PSA-NCAM ϩ cells present at the surface of…”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, unknown): “Derivation of tripotent neural stem cells using FGF may be a similar instance (Gabay et al., 2003; Pollard et al., 2008).”
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “Moreover, recent studies have raised the possibility that NSCs established with a systematic exposure to growth factors may not reflect the properties of in vivo NSCs but rather display acquired properties that are not evident in vivo (Gabay et al., 2003).”
Origins of Cortical Interneuron Subtypes (2004, background): “Alternatively, the culture conditions, including the addition of FGF2 after the donor’s first day in vitro, may have resulted in the “ventralization” of some cortical progenitors (Gabay et al., 2003).”
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “Indeed, Olig2 has recently been found to be induced in spinal cord precursor cells and in neurospheres cultured in FGF-2, indicative of a relaxation of developmental specification [50,51].”
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. (2010, background): “However, culturing these cells with EGF and FGF2 promotes expression of glial transcription factors, such as Olig2 (Gabay et al., 2003; Hack et al., 2004), and only a few neurons are generated from cells cultured as neurospheres, whereas aNSCs in vivo generate mostly neurons.”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Moreover, some neural stem cell populations that have been considered homogeneous based on experiments performed in culture are quite heterogeneous in terms of fate and even developmental potential in vivo (Gabay et al., 2003; Merkle et al., 2007).”
Neuronal fate determinants of adult olfactory bulb neurogenesis (2005, background): “Whereas Olig2 promotes a transit-amplifying precursor state, Pax6 opposes this role and promotes progression toward the neuronal lineage consistent with their role in neurosphere culture”