Specification of motoneurons from human embryonic stem cells
By Xue-Jun Li, Z. Du, E. Żarnowska, M. Pankratz, Lauren O Hansen, R. Pearce, Su-Chun Zhang. Nature Biotechnology, 2005
826 citations recorded by the source corpus.
Subfields: Developmental Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f234e2c15c1bb6d485aeb7a8b003a5c819907bbd
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In Developmental Neuroscience
- Z. Kokaia
- O. Lindvall
- V. Tabar
- Nicholas D. Socci
- Yechiel Elkabetz
- Georgia Panagiotakos
- L. Studer
- D. Surmeier
In Molecular Biology
- V. Tabar
- M. Beal
- Nicholas D. Socci
- Yechiel Elkabetz
- Georgia Panagiotakos
- James A. Thomson
- Michel Sadelain
- L. Studer
Citations in the corpus
- Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency (2010, methodology): “In the present study, we used the well-established motoneuron differentiation system (2, 29) to address whether or not human iPSCs can differentiate into functionally specialized neurons.”
- Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury (2005, background): “Although hESCs have been directed to differentiate into multipotent neural precursors (Carpenter et al., 2001; Reubinoff et al., 2001; Zhang et al., 2001; Li et al., 2005), the differentiation protocol that we used here is unique in that it generates a highly purified, specific neural cell type, OPC”
- Stem Cell Organoid Engineering (2016, neutral): “, 2005), and spinal cord motor neurons (Dimos et al., 2008; Li et al., 2005; Soundararajan et al., 2006; Wichterle et al., 2002) (see Petros et al.”
- Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. (2008, background): “These structures comprise cells expressing early neuroectodermal markers such as Pax6 and Sox1 and are capable of differentiating into various region-specific neuronal and glial cell types in response to appropriate developmental cues (Perrier et al. 2004; Li et al. 2005).”
- Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD (2011, methodology): “1h) partitioned the three induction conditions into (1) LSB: dorsal forebrain; (2) LSB/S/F8: ventral/hypothalamic; (3) LSB/S/F8/CHIR: midbrain DA identity.”
- Stem cells for the treatment of neurological disorders (2006, background): “Recent reports have shown that it is possible to generate lower motor neurons in vitro from stem cells of various sources, including ES cells and those from the fetal CN”
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling (2009, result): “Whereas previous studies had suggested that PAX6 preceded SOX1 expressio”