Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure

By David H. Epstein, Kenzie L. Preston, J. Stewart, Y. Shaham. Psychopharmacology, 2006

629 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Epidemiology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/e57e08d878cbf447b2454ab0881a59324d331fd5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Peters
2. J. Steketee
3. C. O'Brien
4. Gregory J. Quirk
5. Peter W. Kalivas
6. J. Becker
7. Marilyn Carroll
8. Brigitte L. Kieffer

In Epidemiology

1. Marilyn Carroll
2. C. O'Brien
3. Peter W. Kalivas
4. J. Perry
5. J. Steketee

In Social Psychology

1. Peter W. Kalivas
2. J. Peters
3. J. Becker
4. Marilyn Carroll
5. Brigitte L. Kieffer
6. Gregory J. Quirk
7. J. Perry
8. K. Befort

Citations in the corpus

• Neurobiology of the incubation of drug craving (2011, neutral): “Finally, it is beyond the scope of this review to discuss clinical implications of incubation of drug craving, a topic that has been discussed previously (for reviews see [40, 107]).”
• Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “…model of relapse involves training rats to self-administer a drug, placing the animal in forced abstinence either with or without extinction training, then re-exposing the animals to the drug context, cues specifically paired with drug delivery, stress or the drug itself (Epstein et al, 2006).”
• Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “Following extinction, cocaine seeking can be reinstated by presenting a discrete cue that was paired with cocaine delivery, low doses of cocaine itself, or stress (De Wit and Stewart 1981; Shaham et al. 2003; Epstein et al. 2006).”
• The role of impulsive behavior in drug abuse (2008, background): “, stress, drug-associated cues, drug exposure) reinstate responding in this model (Shalev et al. 2002; Epstein et al. 2006).”
• Reward Processing by the Opioid System in the Brain (2009, positive): “Craving for drug(s) persists over years after the cessation of drug taking and often leads to relapse, another feature of human addiction that was transposed to animals using protocols of drug reinstatement (111, 179, 181, 334).”
• Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior (2011, methodology): “However, the construct validity of the reinstatement model has also been questioned (Epstein et al., 2006).”