Cell death modalities: classification and pathophysiological implications

By L. Galluzzi, M. Maiuri, Ilio Vitale, H. Zischka, M. Castedo, L. Zitvogel, Guido Kroemer. Cell Death and Differentiation, 2007

830 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a8f28536cfd812603acc1791ebd865dda23e383b

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Citations in the corpus

Systemic effects of local radiotherapy (2009, neutral): “Conversely, at doses sufficient to directly provoke significant cell death, radiation induces specific signals of danger that are sensed by innate immune cells such as dendritic cells, and lead to the activation of an adaptive immune response [4].”
Lysosomal membrane permeabilization in cell death (2008, background): “…and pathological cell death have been classified according to morphological criteria into at least three categories: type I cell death or apoptosis; type II cell death or autophagic cell death; and type III cell death or necrosis (Clarke, 1990; Kroemer et al., 2005; Galluzzi et al., 2007).”
The role of defective clearance of apoptotic cells in systemic autoimmunity (2010, background): “Although apoptosis seems to be the most common type of programmed cell killing, further PCD pathways exist, including autophagy-associated cell death and caspase-independent cell death pathways”
Radiation-induced cell death mechanisms (2010, background): “The mitotic catastrophes occur during mitosis or as a result of an aberrant mitosis [ 67 ].”
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014, methodology): “First, when this classification was formulated, necrosis (as defined by morphologic features) was considered as a strict equivalent of ACD, whereas apoptosis (as defined by morphologic features) was viewed as the sole programmed subroutine of cell death.(11) Along similar lines, apoptosis was miscon”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “Thus, in 1973 Schweichel and Merker(4) proposed a classification of several cell death modalities, including ‘type I cell death’ associated with heterophagy, ‘type II cell death’ associated with autophagy and ‘type III cell death’, which was not associated with any type of digestion, corresponding t”
Cell Death Signaling. (2015, background): “general, there are three types of cell death, defined in large part by the appearance of the dying cell: apoptosis (also known as type I cell death), autophagic cell death (type II), and necrosis (type III) (Galluzzi et al. 2007).”
Consensus guidelines for the detection of immunogenic cell death (2014, background): “Finally, one of the major morphological modifications of apoptosis (and hence of ICD) is nuclear condensation (pyknosis).(1,2,95) Also this process can be conveniently monitored by fluorescence microscopy, either in cells that constitutively express a GFP- or red fluorescent protein (RFP)-tagged var”
Bcl-2 family members: Dual regulators of apoptosis and autophagy (2008, background): “(2) C-Jun-N’-terminal kinase 1 (JNK1)-mediated phosphorylation of Bcl-2 during starvation can disrupt its interaction with Beclin 1, leading to autophagy induction.”
Classification of cell death (2005, positive): “Although the expression ‘autophagic cell death’ is a linguistic invitation to believe that cell death is executed by autophagy, the term simply describes cell death with autophagy.(15,16,42) Thus far, involuting Drosophila melanogaster salivary glands provide the only in vivo evidence that the knock”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “culminating with phagocytic uptake and consequent lysosomal degradation; and (3) type III cell death or necrosis, displaying no distinctive features of type I or II cell death and terminating with the disposal of cell corpses in the absence of obvious phagocytic and lysosomal involvement [23, 24].”
Apoptosis in cancer: from pathogenesis to treatment (2011, methodology): “While many biochemical assays and experiments have been used in the detection of apoptosis, the Nomenclature Committee on Cell Death (NCCD) has proposed that the classification of cell death modalities should rely purely on morphological criteria because there is no clear-cut equivalence between ult”