Classification of cell death

By G. Kroemer, L. Galluzzi, P. Vandenabeele, J. Abrams, Es Alnemri, Eh Baehrecke, M. Blagosklonny, W S El-Deiry, P. Golstein, Douglas R. Green and 12 more. Cell Death and Differentiation, 2005

2,925 citations recorded by the source corpus.

Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposes unified criteria for the definition of cell death and of its different morphologies, while formulating several caveats against the misuse of words and concepts that slow down progress in the area of cell death research. Authors, reviewers and editors of scientific periodicals are invited to abandon expressions like ‘percentage apoptosis’ and to replace them with more accurate descriptions of the biochemical and cellular parameters that are actually measured. Moreover, at the present stage, it should be accepted that caspase-independent mechanisms can cooperate with (or substitute for) caspases in the execution of lethal signaling pathways and that ‘autophagic cell death’ is a type of cell death occurring together with (but not necessarily by) autophagic vacuolization. This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including ‘entosis’, ‘mitotic catastrophe’, ‘necrosis’, ‘necroptosis’ and ‘pyroptosis’.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/def5e631b8e661635e25d9842e9f7521df43f440

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. P. Boya
3. N. Mizushima
4. Beth Levine
5. Alec C. Kimmelman
6. D. Klionsky
7. Douglas R. Green
8. L. Galluzzi

In Immunology

1. Guido Kroemer
2. Heiko Blaser
3. D. Brenner
4. T. Mak
5. N. Mizushima
6. L. Zitvogel

In Molecular Biology

1. Guido Kroemer
2. P. Boya
3. T. Mak
4. N. Mizushima
5. Beth Levine
6. D. Klionsky
7. L. Galluzzi
8. Douglas R. Green

Citations in the corpus

• Autophagy: process and function. (2007, background): “However, there is almost no evidence supporting this speculation under physiological or pathological conditions (Edinger and Thompson 2004; Debnath et al. 2005; Kroemer et al. 2005).”
• Cell death localization in situ in laboratory reared honey bee (Apis mellifera L.) larvae treated with pesticides (2011, methodology): “Moreover, cell death detection and quantification can be more accurate and potential artifacts can be reduced by using more than one assay [25].”