Lysosomal membrane permeabilization in cell death

By P. Boya, Guido Kroemer. Oncogene, 2008

1,334 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/accc4947dfd72cf76a879e97c9b0ec81921a7a5f

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Citations in the corpus

Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “In contrast to autophagy hyperactivation, autophagy failure is commonly linked to a lysosome dependent form of cell death (Boya and Kroemer, 2008) which is relevant to the loss of neurons in various neurodegenerative diseases.”
A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis (2014, positive): “The mechanism of NE release shares similarities with models that have been proposed to explain the release of cathepsins from intact lysosomes and the permeabilization of mitochondrial membranes during cell death (Boya and Kroemer, 2008).”
Pathogenic Lysosomal Depletion in Parkinson's Disease (2010, background): “Because weakly basic lysosomotropic amines such as ammonium chloride are known to induce LMP by alkalinizing the intralysosomal acidic pH (Boya and Kroemer, 2008) and MPP is a quaternary ammonium compound able to alkalinize intracellular pH in some cellular settings (Dudley et al., 2000), we ruled…”
Anti-apoptosis and cell survival: a review. (2011, background): “proteases that may themselves trigger cell death [31].”
The inflammasome: an integrated view (2011, background): “This observation raises the question as to how these poorly diffusible and rapidly quenched signals could activate cytoplasmic pathways leading to inflammasome activation (74, 104).”
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010, background): “However, the release of NE is reminiscent of the lysosomal membrane permeabilization observed during cell death (Boya and Kroemer, 2008).”
Lysosomal cell death at a glance (2013, background): “In addition, many other molecules regulate LMP, as reviewed elsewhere (Boya and Kroemer, 2008; Kirkegaard and Jäättelä, 2009; Kroemer and Jäättelä, 2005; Repnik et al., 2012).”
Metabolic control of cell death (2014, background): “Lysosome-disrupting agents can actually provoke a nonapoptotic form of cell death (69), leaving this possibility open.”