L-arginine availability regulates T-lymphocyte cell-cycle progression.

By P. Rodriguez, D. Quiceno, Augusto Ochoa. Blood, 2007

921 citations recorded by the source corpus.

Subfields: Biochemistry, Immunology

View Paper: https://www.semanticscholar.org/paper/a8d9b2351a878cc4f7848ab39f2c2578bad8e11c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Mellor
2. D. Munn
3. M. Munder
4. Augusto Ochoa
5. P. Rodriguez

In Immunology

1. M. Munder
2. D. Gabrilovich
3. P. Rodriguez
4. Augusto Ochoa
5. V. Bronte
6. D. Munn
7. A. Mellor
8. F. Sallusto

Citations in the corpus

• IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance (2016, positive): “Then, via a process that is not yet well understood, GCN2 inhibits the activity of the mTORC2 complex, and prevents it from phosphorylating Akt on its activating Ser473 site [86].”
• Myeloid derived suppressor cells (2013, background): “Furthermore, it may inhibit the cell cycle regulatory proteins cyclin D3 and cyclin-dependent kinase 4, which blocks T-cell proliferation.(25) By contrast, high levels of NO, produced by MDSC iNOS2, are thought to interfere with T-cell JAK/STAT signaling proteins required for numerous T-cell functio”
• Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “Moreover, L-arginine deprivation was suggested to alter mRNA expression and cause cell cycle arrest in G0-G1 phase as a consequence of the increase in intracellular levels of uncharged tRNAs, which in turn activate GCN2 to phosphorylate EIF2a (96).”
• Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives (2008, background): “Therefore, the expression of cyclin D3 and cdk4 in the absence of L-Arg are blocked through transcriptional, post-transcriptional, and translational mechanisms (89).”
• Arginase: an emerging key player in the mammalian immune system (2009, background): “Also, an arrest of T cells in the G0-G1 phase of the cell cycle, associated with the absence of up-regulated cyclin D3 and cyclin-dependent kinase 4 (cdk4) was seen upon L-arginine depletion (Rodriguez et al., 2007).”
• Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes (2009, neutral): “flow cytometry after 96 h as previously described (12).”
• L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “In addition, degradation of L-arginine by myeloid-derived suppressor cells leads to reduced expression of the CD3z chain, resulting in impaired T cell responsiveness (Bronte and Zanovello, 2005; Rodriguez et al., 2007).”