Infections as a major preventable cause of human cancer

By H. Kuper, Hans-Olov Adami, D. Trichopoulos. Journal of Internal Medicine, 2000

817 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/a819ac006ab1e449f13e99e672b7d1028ab602c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. W. Zou
2. M. Karin
3. F. Greten
4. D. Hanahan
5. T. Lawrence

In Immunology

1. M. Karin
2. Lieping Chen
3. W. Zou
4. F. Greten
5. T. Lawrence
6. V. Nizet
7. D. Hanahan
8. G. Dranoff

In Oncology

1. M. Karin
2. F. Greten
3. Lieping Chen
4. W. Zou
5. T. Lawrence
6. V. Nizet
7. E. Koivunen
8. M. Björklund

Citations in the corpus

• Nuclear factor-κB in cancer development and progression (2006, background): “Collectively, underlying infections and inflammation are linked to 15–20p of all cancer death”
• Immunosuppressive networks in the tumour environment and their therapeutic relevance (2005, background): “Not only do 15% of cancers worldwide have a direct infectious origi”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “…and malignant transformation, as exemplified by strong associations between chronic gastritis, hepatitis, or colitis and increased risk of primary carcinoma in the corresponding organ (Kuper et al., 2000) or the link between chronic gingivitis and insulin resistance (Pucher and Stewart, 2004).”
• Mechanisms and consequences of intestinal dysbiosis (2017, background): “Around 15% of all cases of cancer are linked to a viral or bacterial infection [198].”
• Inhibitory B7-family molecules in the tumour microenvironment (2008, background): “Not only do up to 15% of cancers worldwide have a direct infectious origi”
• NF-κB: linking inflammation and immunity to cancer development and progression (2005, background): “2 million cases of infection-related malignancies per yea”
• Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. (2010, background): “C variously influence cancer cell proliferation, angiogenesis, invasion, and metastasis (De Marzo et al., 1999; Kuper et al., 2000; van Kempen et al., 2006).”
• Gelatinase-mediated migration and invasion of cancer cells. (2005, background): “It has been estimated that over 15% of the malignancies have an infectious origin (Kuper et al., 2000).”
• Inflammation and cancer (2002, neutral): “The inflammatory component of a developing neoplasm may include a diverse leukocyte population — for example, neutrophils, dendritic cells, macrophages, eosinophils and mast cells, as well as lymphocytes — all of which are capable of producing an assorted array of cytokines, cytotoxic mediators incl”
• Cytokines in cancer pathogenesis and cancer therapy (2004, background): “In these pathologies, Epstein–Barr virus, human herpes virus-8 and papilloma virus function directly as transforming agent”