Gelatinase-mediated migration and invasion of cancer cells.

By M. Björklund, E. Koivunen. Biochimica et Biophysica Acta, 2005

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Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation (2006, background): “MMP-9 expression and activation can be induced by many inflammatory cytokines such as tumour necrosis factor-a (TNF-a), interleukin-1 (IL-1), interferon-c (IFNc), IL-2, but also decreased by IL-10 and activation IL-4 (8,42,43).”
Physiology and pathophysiology of matrix metalloproteases (2010, background): “MMPs thus contribute to the generation of protein species with vastly differing activities from a single, original gene product.”
Matrix metalloproteinases and tumor metastasis (2006, background): “In many cancers, elevated plasma levels of soluble gelatinases have been positively correlated with higher incidence of metastases in different cancer types and considered as a valuable prognostic factor [23, 32].”