The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

By R. Cardone, V. Casavola, S. Reshkin. Nature Reviews. Cancer, 2005

875 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/a7bcd7b3277d76ae927bc86d784eb7dbbfc3b31d

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Citations in the corpus

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. (2006, background): “Acute exposure of tumor cells to acidic pHe has been shown to cause transient up-regulation of a large number of genes (5, 24, 30, 33), consistent with the transient nature of the acidity-induced increase in metastatic potential in our melanoma cells.”
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. (2010, neutral): “4 [26,27].”
Hypoxia and cancer (2007, background): “Hypoxic tumours also show an extracellular pH (pHe) that is lower than that of corresponding normal tissue [8].”
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases (2011, background): “In addition, nutrient and serum deprivation leads to the formation of pro-angiogenic reactive oxidative specie”
Hypoxia signalling in cancer and approaches to enforce tumour regression (2006, background): “The concern about anti-angiogenic therapy is the inherent selection of cancer cells that adapt to more hypoxic conditions and, in particular, to tumour acidosis, which is a hallmark of anaerobic glycolysi”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “The process of lactate elimination progressively increases the acidity of the tumor extracellular space as the monocarboxylate transporter also simultaneously exports one proton out of tumor cells with each lactate molecule (Dimmer et al., 2000; Cardone et al., 2005).”
Acidic extracellular microenvironment and cancer (2013, background): “To secrete acidic metabolites, NHE1 and the H-lactate co-transporter are involved [114].”