Shedding microvesicles: artefacts no more.

By Emanuele Cocucci, G. Racchetti, J. Meldolesi. Trends in Cell Biology, 2009

1,770 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a7295ede886ec080555ad16195cd0db2ce7c0911

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Citations in the corpus

Secreted monocytic miR-150 enhances targeted endothelial cell migration. (2010, result): “It appears likely that MVs from cultured THP-1 cells represent primarily exosome-like vesicles, a finding that concurs with the findings of others (Cocucci et al., 2009; Simons and Raposo, 2009; Gibbings et al., 2009).”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, neutral): “Exosomes are nano-vesicles of 50–140 nm in size that contain proteins, mRNA, and microRNAs (miRNAs) protected by a lipid bilayer (Kahlert and Kalluri, 2013; Cocucci et al., 2009; Simons and Raposo, 2009; Simpson et al., 2008; Thé ry et al., 2002).”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “Trends Biochem Sci (2003) 28(2):106–12.”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “In four recent reviews, vesicles were classified into between two and six major different types (Cocucci et al., 2009; Théry et al., 2009; Beyer and Pisetsky, 2010; Mathivanan et al., 2010).”
High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients (2009, background): “The ELISA we developed is based on the presence on exosome of proteins shared with cytoplasmic organelles such as endosomes and lysosomes (Rab-5b and CD63), whose membranes are not shed or recycled as for plasma membrane structures, thus excluding the possible presence of structures deriving from me”
Microvesicles: mediators of extracellular communication during cancer progression (2010, background): “The roles of microvesicles have been best studied in processes such as inflammation and coagulation, and have been described in some excellent reviews (Cocucci et al., 2009; Hugel et al., 2005; Ratajczak et al., 2006b).”
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs (2012, background): “We refer to this heterogeneous collection of vesicles, which are formed in distinct ways and vary in size, as extracellular vesicle”
Shedding light on the cell biology of extracellular vesicles (2018, neutral): “…a strong microvesicle release is induced by increased concentration of Ca 2+ , which by activating scramblase and calpain leads to a loss of membrane phospholipid asymmetry and the reorganization of the cytoskeleton (see above) or by the activation of protein kinase C [G] by phorbol esters 130 .”
Exosomes--vesicular carriers for intercellular communication. (2009, background): “For example platelets secrete exosomes after activation in order to regulate coagulation events [1].”