Secreted monocytic miR-150 enhances targeted endothelial cell migration.

By Yujing Zhang, Dan-Qing Liu, Xi Chen, Jing Li, Limin Li, Zhen Bian, F. Sun, Jiuwei Lu, Yuan Yin, Xing Cai and 12 more. Molecules and Cells, 2010

1,210 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1c597157209a9be728c000e7a0c3dfbe78f04667

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Citations in the corpus

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma (2011, background): “Extracellular miRNAs have been proposed as a means of intercellular communication (6, 14, 16), and exosome-mediated transfer of miRNA between cells has been reported in cell culture (15) and from plasma-derived microvesicles to endothelial cells in the experimental setting (17).”
Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? (2012, background): “Along these lines, Zhang et al10 identified miR-150 as an miRNA that is packaged into MVs by human blood cells and monocytic cells (THP1) in abundant quantities.”
Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery* (2014, background): “miRNAs, protected in exosomes against degradation, is an important regulator of gene expression at the post-transcriptional level (36, 37).”
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper (2017, methodology): “reported a relative depletion or even absence of AGOs from EVs,[32,139] while others detect significant amount of AGOs.[76,140,141] Workshop participants discussed”
Overview of MicroRNA Biology (2015, background): “These include targets with G:U wobble pairing or bulges within the seed, illustrated by one of the original let-7 binding sites inlin-41.”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “Blood cell-derivedEVs, containing miR-150 (more abundant in atherosclerotic patients) have been shown to enter endothelial HMEC-1 cells, delivering miR-150, which reduced c-Myb expression and enhanced cell migration of HMEC-1 cells (179).”
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “Incubation of microvascular endothelial cells with these EVs downregulates the miR-150 target gene c-Myb, a transcription factor involved in endothelial cell migration (Kopecki et al., 2007; Xiao et al., 2007; Zhang et al., 2010; Zhang et al., 2010b).”