Microvesicles: mediators of extracellular communication during cancer progression

By Vandhana Muralidharan-Chari, James W. Clancy, Alanna Sedgwick, C. D’Souza-Schorey. Journal of Cell Science, 2010

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Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, neutral): “On the other hand, transferrin receptors, highly enriched in exosomes, appear notably to be missing in microvesicles [68].”
Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “2), the cellular machineries involved in their formation and release are likely to differ, although mechanistic elements may be D ow nloaded from http://rupress.org/jcb/article-pdf/200/4/373/1262520/jcb_201211138.pdf by guest on 18 N ovem ber 2022 377Extracellular vesicles • Raposo and Stoorvogel ac”
Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. (2011, background): “Tumor cells produce large amount of MVs that may enter in the circulation and in other biological fluids (4, 5).”
Targeting Tumor Microenvironment for Cancer Therapy (2019, background): “Moreover, TCDEs secretion increases with cancer progression, with epithelial tumor cells secreting less exosomes than tumor cells presenting a mesenchymal phenotype [133,142].”