The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
By Zhiyuan Yang, Qingwei Zhu, K. Luo, Qiang Zhou. Nature, 2001
690 citations recorded by the source corpus.
Subfields: Molecular Biology, Virology
View Paper: https://www.semanticscholar.org/paper/a67cb3ac27b4e6c040e14deffff4c5204d1796e2
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In Molecular Biology
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Citations in the corpus
- Evolution and functions of long noncoding RNAs. (2009, background): “The 7SK noncoding RNA (331 nucleotides) represses transcript elongation by Pol II in complex with the elongation factor P-TEFb by downregulating its kinase activity (Nguyen et al., 2001; Yang et al., 2001).”
- Non-coding RNA. (2006, background): “In addition, the small conserved nuclear RNA 7SK inhibits the kinase activity of the CDK9/cyclin T complex, leading to reduced phosphorylation of RNA polymerase II and a reduction in transcription (30).”
- The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “The activity of this transcription elongation factor P-TEFb, which comprises the kinase CDK9 and cyclin T, is regulated in a specific and reversible manner by small nuclear RNA molecules (608, 609).”
- Recruitment of RNA polymerase III to its target promoters. (2002, background): “1986), whose RNA product has been recently implicated in the regulation of the CDK9/cyclin T complex (Nguyen et al. 2001; Yang et al. 2001).”
- The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. (2006, methodology): “In this context, differences amongst Dlx/dll members were not detected (Zerucha et al. 2000).”
- Elongation by RNA polymerase II: the short and long of it. (2004, background): “In addition, two separate studies discovered that P-TEFb associates with the small nuclear RNA (snRNA) 7SK, a 330-nt-long snRNA that is evolutionarily conserved (Reddy et al. 1984; Nguyen et al. 2001; Yang et al. 2001).”