Immune inhibitory receptors.
By J. Ravetch, L. Lanier. Science, 2000
1,403 citations recorded by the source corpus.
Subfields: Immunology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/a636ce8a1ca46989e4450927a049814c876917d5
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In Immunology
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Natural killer cells, viruses and cancer (2001, background): “HLA-E binds to the inhibitory NK receptor CD94/NKG2A (CD159a) and blocks NK-cell-mediated cytotoxicit”
- Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance (2003, background): “The inhibitory FcgRIIB and KIR signal via ITIM domains that are substrates for src-family tyrosine kinases and that in turn activate PIP3 phosphatase (SHIP) for FcgRIIB or tyrosine phosphatase (SHP-1, -2) for KIR (Ravetch and Lanier, 2000).”
- Fcγ receptors as regulators of immune responses (2008, background): “The family of Fc receptors (FcRs) for IgG (FcγRs) provides a prime example of how simultaneous triggering of activating and inhibitory signalling pathways sets thresholds for cell activation and thus generates a well-balanced immune respons”
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells (2011, background): “A prototypic ITIM has the sequence I/V/L/SXYXXL/V/F (where 'I/V/L/S' indicates isoleucine, valine, leucine or serine; 'X' indicates any amino acid; 'Y' is the tyrosine that can be phosphorylated; and 'L/V/F' indicates leucine, valine or phenylalanine”
- The effect of phosphatases SHP‐1 and SHIP‐1 on signaling by the ITIM‐ and ITAM‐containing Fcγ receptors FcγRIIB and FcγRIIA (2003, background): “It has been classified as an inhibitory receptor as a result of the presence of the ITIM sequence in its cytoplasmic domain, and it has been shown to attenuate immune responses in B cells, mast cells, and monocytes following coaggregation with ITAM-containing immunoreceptors [5].”
- Roles of Fc receptors in autoimmunity (2002, background): “By contrast, FcγRIIb — which is the most widely expressed FcR — contains an ITIM, which inhibits ITAM-mediated cellular activation triggered by the binding of antibody or ICs to activating FcR”
- Siglecs and their roles in the immune system (2007, background): “Classically, receptors with ITIMs function as inhibitory receptors and suppress activation signals that emanate from receptors associated with immunoreceptor tyrosine-based activation motifs (ITAMs) through the recruitment of tyrosine and inositol phosphatase”
- Up on the tightrope: natural killer cell activation and inhibition (2008, background): “When ITIM-bearing receptors engage their ligands, the tyrosine residue is phosphorylated, probably by a Src family kinase, resulting in the recruitment of the lipid phosphatase SHIP-1—which degrades phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-3,4-bisphosphate—or the tyrosine pho”
- The Role of the Anaphylatoxins in Health and Disease (2009, neutral): “This coupling of activating and inhibitory signals from cellular receptors which recognize similar ligands has emerged as a general principle during evolution in which the overall response is determined by the relative contribution of each signaling pathway (Ravetch and Lanier, 2000).”
- Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “Similarly, NKG2A, LIR-1, and mouse Ly49 receptors also contain cytoplasmic ITIMs that are capable of recruiting SHP-1 (28).”
- IgEb immune complexes activate macrophages through FcγRIV binding (2007, background): “Coordination of the activating and inhibitory functions of FcRs is important for the successful initiation, amplification and termination of immune response”