Fcγ receptors as regulators of immune responses

By F. Nimmerjahn, J. Ravetch. Nature reviews. Immunology, 2008

2,627 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/170464e1e8d01f2cf2cd59ca76db756af7482d20

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Citations in the corpus

Glycosylation as a strategy to improve antibody-based therapeutics (2009, background): “These effector ligands include three structurally homologous cellular Fc receptor types (FcγRI, FcγRII and FcγRIII), the C1q component of complement and the neonatal Fc receptor (FcRn”
From Vaccines to Memory and Back (2010, positive): “The B cell system is also under homeostatic control and there are mechanisms for regulating naïve and memory B cell numbers as well as total immunoglobulin levels in the serum (Nimmerjahn and Ravetch, 2008; Sanz et al., 2008).”
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma (2013, background): “In mice, ADCC is regulated predominantly by the low-affinity receptors FcRIII and FcRIV (Nimmerjahn et al., 2005; Nimmerjahn et al., 2010; Setiady et al., 2010), and to a lesser extent by the highaffinity FcRI (Fossati-Jimack et al., 2000; Tedder et al., 2006; Hamaguchi et al., 2006).”
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis (2017, background): “For instance, immunoglobulin G (IgG), when specifically bound to microbial surface antigens, associates with fragment crystallizable γ receptors (FcγRs) in phagocytes, which recognizes their fragment crystallizable (Fc) region [15,16].”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “The concept and existence of the ITIM was first established with FcγRIIb, which inhibits B cell receptor signaling by recruiting the inositol phosphatase SHIP when coligated through binding of IgG immune complexes (150, 152).”