Roles of Fc receptors in autoimmunity
By T. Takai. Nature reviews. Immunology, 2002
660 citations recorded by the source corpus.
The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular branches of the immune system, and they have important functions in the activation and down-modulation of immune responses. Balanced signalling through activating and inhibitory FcRs regulates the activity of various cells in the immune system. Recent work in animal models indicates that the development of many human autoimmune diseases might be caused by impairment of the FcR regulatory system. This review provides an overview of the mechanisms of FcR-based immune regulation and describes how autoimmune disease might result from its dysfunction.
Subfields: Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/bedb6582e48a4f162194e085c0efa78302f02ca8
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In Immunology
In Molecular Biology
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- New IBD genetics: common pathways with other diseases (2011, background): “H131R mutation in FCGR2A, important for removal of immune complexes, is another example.(71) The Arg131 mutation is functionally associated with SLE, MS and T1DM, but it is the His131 variant, that has greater affinity for IgG immune complexes, which is associated with ulcerative colitis.”
- The Role of the Anaphylatoxins in Health and Disease (2009, positive): “Given that FcγRs, in particular FcγRIIB, contributes to the development of autoimmunity (Takai, 2002), it will be important to delineate in future studies whether the regulatory link between C5aR and FcγRIIB will also affect afferent immunity and the development of autoimmune diseases such as SLE.”
- The M1 and M2 paradigm of macrophage activation: time for reassessment (2014, background): “FcR KO animals have normal macrophage numbers, but their opsonic phagocytic capacity is highly impaired [50].”