Siglecs and their roles in the immune system

By P. Crocker, J. Paulson, A. Varki. Nature reviews. Immunology, 2007

1,962 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e8df2040c661a3233ec289471736142ae8b04357

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Citations in the corpus

The genetics of Alzheimer disease: back to the future. (2010, background): “…lectins that are believed to promote cell-cell interactions and to regulate the functions of cells in the adaptive and innate immune systems (Crocker et al., 2007; von Gunten and Simon, 2006), both involved in contributing to the inflammatory reactions observed in the brains of AD patients.”
The genetics of Alzheimer disease. (2012, background): “These molecules promote cell–cell interactions that regulate the innate immune system (Crocker et al. 2007), including inflammation.”
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation (2009, background): “How do endogenous lectins influence T cell homeostasis? Most lectins, including C-type lectins and sialic acid-binding immunoglobulin-like lectins (Siglecs), are associated with the cell surface of antigen-presenting cells (APCs), where they can modulate T cell signalling and survival through glyc”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “Siglecs and their roles in the immune system.”
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta (2013, positive): “regulate several aspects of innate immunity (Crocker et al., 2007; Paulson et al., 2012).”
Protein-glycan interactions in the control of innate and adaptive immune responses (2008, background): “In addition, several carbohydrate structures, such as Tn (GalNAc-α-Ser/Thr, CD175), sialyl Tn (N-acetylneuraminic acid-α6-GalNAc-α-Ser/Thr, CD175s), Thomsen-Friedenreich disaccharide (Gal-β(1-3)-GalNAc, CD176) and (sialylated) Lewis antigens (CD15s) are highly upregulated in malignant cells and have”
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. (2014, background): “In contrast, siglecs have diversified to take advantage of the many linkages and contexts in which sialic acids are found on tissues (98).”
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease (2011, positive): “CD33 is a member of the sialic-acid-binding immunoglobulin-like lectins (Siglec) family which are thought to promote cell-cell interactions and regulate functions of cells in the innate and adaptive immune systems 26 .”
Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins (2015, background): “In consequence of this topology, Sias are key elements of the glycotopes of many regulatory cellular lectins (Crocker et al., 2007; Schauer, 2009).”
The safety and side effects of monoclonal antibodies (2010, background): “Monkey and human lymphocytes have differences in the expression of sialic acid-binding Ig-like lectins (SIGLECs”
Human milk oligosaccharides: every baby needs a sugar mama. (2012, background): “Siglecs are involved in the immune system in multiple ways (Crocker et al. 2007) and have been shown to bind sialylated HMO (Koliwer-Brandl et al.”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “…or lectins results in production of proinflammatory cytokines and can be proinflammatory (i.e., “immunogenic”), pathogen uptake via Fc receptors can also inhibit inflammation (Crocker et al. 2007; Hamerman and Lanier 2006; Long 2008; Underhill and Goodridge 2007; van Lookeren Campagne et al. 2007).”
Mammalian glycosylation in immunity (2008, neutral): “The BCR forms complexes with immunoregulatory glycoproteins that modulate the threshold of BCR activation, including the lectin CD22 (also known as Siglec-2), a member of the Siglec (sialic-acid-binding immunoglobulin-like lectin) famil”
The sweet and sour of cancer: glycans as novel therapeutic targets (2005, background): “and pathogen internalization, siglec functions include immunoregulatory processes [103, 105, 109], such as”
PD-1 signaling in primary T cells (2009, background): “Members of the CD33-Siglec family are expressed on the surface of the majority of immune cells as well as on cells in the central nervous system (34).”