The search for endogenous activators of the aryl hydrocarbon receptor.
By L. Nguyen, Christopher A. Bradfield. Chemical Research in Toxicology, 2008
726 citations recorded by the source corpus.
Subfields: Cancer Research, Health, Toxicology and Mutagenesis
View Paper: https://www.semanticscholar.org/paper/a5e5aa601f11962aae411b42d4f975b33f5482f2
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Health, Toxicology and Mutagenesis
Citations in the corpus
- Oral tolerance (2011, background): “In humans, the primary environmental exposure to TCDD is via food (121, 123) and many food constituents, such as plant flavonoids and indoles, or bacterial tryptophan products are agonists of AHR and may activate the AHR pathway in the gut (124).”
- 450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy (2012, background): “This complex binds DNA regulatory sequences, termed xenobiotic response elements (XRE)s, and initiates the expression of CYP1A1 and other genes involved in detoxification of these chemicals (Nguyen and Bradfield 2008).”
- PubChem structure–activity relationship (SAR) clusters (2015, background): “In addition, because it is also involved in the regulation of cell proliferation and differentiation [50, 51], interest in AhR biology has grown, beyond a toxicological perspective, to its role in normal physiology and development of mammalian organisms [46].”
- Interleukin-22: immunobiology and pathology (2015, background): “Potential AhR ligands could be derived endogenously, from the diet, or from the gut microbiota (190), including indol-3-carbinol, 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (193, 194).”
- The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells (2011, background): “Although the endogenous Ahr ligands remain elusive, 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoprod- uct, has been proposed to be a physiological agonist for Ahr (Nguyen and Bradfield, 2008).”
- Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. (2011, background): “…bind and be activated or inhibited by a remarkably wide variety of structurally dissimilar compounds (Denison and Nagy, 2003; Denison et al., 1998a; Nguyen and Bradfield, 2008), and significant species-specific differences in ligand-binding specificity and ligand-specific AhR functionality have…”
- Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “Additional xenobiotic AhR ligands have been identified, differing in their structures and affinities for the receptor as extensively reviewed elsewhere (Nguyen and Bradfield, 2008).”
- AN INTERACTION BETWEEN KYNURENINE AND THE ARYL HYDROCARBON RECEPTOR CAN GENERATE REGULATORY T CELLS, (2010, background): “We tested each of the commercially available substrates in the kynurenine pathway, and compared their ability to activate the DRE with TCDD. Interestingly, kynurenine itself showed the strongest activity (Fig.”
- Tolerogenic dendritic cells (2016, background): “AhR is a ligand-activated transcription factor activated by a broad array of synthetic and natural agonists [66].”