Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor.
By M. Denison, A. Soshilov, G. He, D. DeGroot, Bin Zhao. Toxicological Sciences, 2011
740 citations recorded by the source corpus.
Subfields: Cancer Research, Health, Toxicology and Mutagenesis
View Paper: https://www.semanticscholar.org/paper/5f53241b0e8514903a7c7d85c8c24840c44d7ef7
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In Health, Toxicology and Mutagenesis
Citations in the corpus
- Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention (2019, methodology): “For anti-estrogenicity assay, mouse hepatoma cells were stably transfected and used [199].”
- Antioxidant defense system is altered by dietary oxidized lipid in first-feeding rainbow trout (Oncorhynchus mykiss) (2014, background): “AhR responds to xenobiotics but also to endogenous compounds such as oxidized low-density lipoproteins with the induction/repression of expression of a large array of genes that can modulate cellular defenses (Denison et al., 2011).”
- Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications (2020, background): “This results in cochaperone dissociation and heterodimerization with the AhR nuclear translocator (ARNT) which acts as a transcription factor, most notably for biotransformation enzymes such as cytochrome P450 1a1 (Denison et al., 2011).”