Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function

By Maurus de la Rosa, S. Rutz, Heike Dorninger, A. Scheffold. European Journal of Immunology, 2004

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CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “that Treg cells may be preferentially using IL-2 as shown in vitro (43), because they require IL-2 for their function and maintenance in vivo (44).”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “To be suppressive, Tregs themselves have to be TCR-activated in the presence of IL-2 (Takahashi et al., 1998; Thornton and Shevach, 1998; de la Rosa et al., 2004; Thornton et al., 2004a,b) while costimulation via CD28 is dispensable (Takahashi et al., 2000).”
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1 (2005, background): “an important modulator of T reg activity, in vivo (39, 40).”
A function for interleukin 2 in Foxp3-expressing regulatory T cells (2005, background): “Finally, studies have suggested that IL-2 is directly required for T reg cell function, and in its absence, T reg cells fail to suppress T cell proliferatio”
IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 (2007, background): “functional properties of natural CD4 CD25 Treg cells (34, 35).”
The regulation of IL-10 production by immune cells (2010, background): “Both IL-2 and IL-4 have been shown to induce IL-10 production after culture of T Reg cells in vitro”