A Cellular MicroRNA Mediates Antiviral Defense in Human Cells

By Charles-Henri Lecellier, P. Dunoyer, K. Arar, J. Lehmann-Che, Stéphanie Eyquem, C. Himber, A. Saïb, Olivier Voinnet. Science, 2005

948 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a4e708152b1d6566c627fbbdb51831f996cf2e59

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Citations in the corpus

Expression of microRNA-146 in rheumatoid arthritis synovial tissue. (2008, background): “Several microRNA exhibit a tissue-specific or developmental stage–specific expression pattern and have been reported to be associated with conditions such as cancer and viral infection (18, 19).”
Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “Studies in human cells have revealed that an endogenous miRNA, miR32, targets the retrovirus PFV-1, suggesting that miRNAs may have an antiviral role (Lecellier et al. 2005).”
MicroRNA functions in animal development and human disease (2005, background): “Function of animal microRNAs in vivo Process microRNA Targets Function Evidence Key citations C. elegans Developmental timing lin-4 microRNA lin-14, lin-28 Stem cell differentaition LOF Lee et al., 1993; Wightman et al., 1993 Developmental timing let-7 microRNA lin-41, hbl-1, Stem cell differentaiti”
microPrimer: the biogenesis and function of microRNA (2005, background): “used antisense locked-nucleic acid (LNA) oligonucleotides, nucleic acid molecules that are modified to dramatically increase their binding affinities, to block miR32 in cultured human cells, a miRNA proposed to mediate innate anti-viral defense (Lecellier et al., 2005).”
Functions of microRNAs and related small RNAs in plants (2006, background): “In mammals, several examples of miRNA-mediated inhibition or enhancement of viral infection have been reporte”
Biological functions of microRNAs: a review (2011, background): “An anti-viral miRNA , which effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells, was the first to be reported [ 24 ].”
microRNA as Biomarkers and Diagnostics (2016, background): “…hepatocarcinogenesis (Murakami et al., 2009). miR-32 effectively restricted the accumulation of the retrovirus JOURNAL OF CELLULAR PHYSIOLOGY primate foamy virus type 1 (a retrovirus akin to HIV-1) in human cells by targeting a primate foamy virus type 1-encoding protein (Lecellier et al., 2005).”
Viruses, microRNAs, and Host Interactions (2010, background): “For example, primate foamy virus type 1 is restricted by miR-32 in 293T cells, while miR-24 and miR-93 have been reported to target VSV RNAs in mice (55, 69).”
Antiviral immunity directed by small RNAs. (2007, neutral): “The miRNA target is the virus itself in the case of the primate foamy retrovirus and vesicular stomatitis virus (Lecellier et al., 2005; Otsuka et al., 2007), whereas a host factor critical to viral gene expression is suppressed in HIV-infected cells (Triboulet et al., 2007 )—both of which are…”
MicroRNA control in the immune system: basic principles. (2009, background): “Thus, miR-32 counteracts the accumulation of primate foamy virus type 1 (PFV-1) in human cells, by directly targeting the PFV-1 genome and causing translation inhibition (Lecellier et al., 2005).”
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes (2007, background): “A defensive role for cellular miRNAs against viral infection has been demonstrated in plants, insects, vertebrates and mammal”