Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement.

By N. Sousa, N. Lukoyanov, M. Madeira, O. Almeida, M. Paula‐Barbosa. Neuroscience, 2000

774 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/a482b4c1d50e14f2629df71e825b7ddb3a453a97

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Citations in the corpus

Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, background): “Effects of chronic glucocorticoid administration on morphology and memory In spite of the fact that glucocorticoids do not work alone, chronic corticosterone treatment by injection or by passive administration in the drinking water are both able to cause dendrites to retract in CA3 hippocampus (Wool”
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “, 2005), however, when the cause of the stress disappears, the hippocampus shows amelioration of the cognitive and synaptic deficits (Sousa et al., 2000; Hoffman et al., 2011).”
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress (2007, background): “However, although no gross structural changes were observed in the CA1 and subiculum, chronic stress imposes functional and structural damage to other hippocampal subfields (Sousa et al., 2000; McEwen, 2001) that may result in functional alterations of the main projecting areas.”
Protective and damaging effects of stress mediators: central role of the brain (2006, background): “374 causes retraction and simplification of dendrites in the CA3 region of the hippocampus.(58,69) Such dendritic reorganization is found in both dominant and subordinate rats undergoing adaptation of psychosocial stress in the visible burrow system, and it is independent of adrenal size.”
Oxidative Stress and the Central Nervous System (2017, positive): “Within the hippocampus, it is well known that the dentate gyrus-CA3 system exhibits structural plasticity with regenerative/remodeling capacity (Popov and Bocharova, 1992; McEwen, 2008; Sousa et al., 2000).”
The concept of allostasis in biology and biomedicine. (2003, background): “Then there is atrophy of pyramidal neurons in the hippocampus and dentate gyrus (McEwen, 1999; Sousa et al., 2000) and inhibition of ongoing neurogenesis in the dentate gyrus (McEwen, 1999) as well as a possible loss of glial cells (Rajkowska et al., 1999).”
Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. (2006, background): “4C,D).”
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus (2003, background): “Other investigators have not only confirmed the repeated stressinduced dendritic debranching in CA3 but have also shown reduced branching of dendrites in DG and CA1 (Chattarji et al., 2000; Sousa et al., 2000).”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “[384] Sousa N, Lukoyanov NV, Madeira MD, Almeida OFX, PaulaBarbosa MM.”
The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, background): “dendritic tree of hippocampal neurons (Sousa et al., 2000; Bessa et al., 2009), and ultimately, loss of granule cells (Jayatissa et al.”