The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress

597 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Stress signalling pathways that impair prefrontal cortex structure and function (2009, unknown): “Chronic stress also disrupts the plastic relationship between the PFC and the hippocampus that is needed for flexible memory consolidatio”
Brain On Stress: Vulnerability and Plasticity of the Prefrontal Cortex Over the Life Course (2013, unknown): “For example, CRS and chronic immobilization caused dendritic shortening in medial prefrontal cortex (Cerqueira et al., 2007; Cook and Wellman, 2004; Liston et al., 2006; Radley et al., 2004) but produced dendritic growth in neurons in basolateral amygdala (Vyas et al., 2002), as well as in…”
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy (2012, background): “Analogous to psychosocial stress in humans, the exposure of adult rodents to adverse events perturbs PFC-derived networks, leading to deficits in LTP, working memory and executive functio”