Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus

By K. Pham, J. Nácher, Patrick R. Hof, Bruce S. McEwen. European Journal of Neuroscience, 2003

694 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/4d5358d76a0f04eb104c76c1b08c9e84205b43b9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Duman
2. R. Hen
3. Bruce S. McEwen
4. E. Gould
5. H. Schmidt
6. B. Leuner
7. J. Snyder
8. Heather A. Cameron

In Developmental Neuroscience

1. R. Hen
2. R. Duman
3. Fred H. Gage
4. E. Gould
5. B. Leuner
6. Bruce S. McEwen
7. D. Abrous
8. Heather A. Cameron

In Neurology

1. E. Gould
2. D. Abrous
3. B. Leuner
4. M. Le Moal
5. Heather A. Cameron
6. M. Koehl
7. R. Duman
8. J. Snyder

Citations in the corpus

• Structural Plasticity and Hippocampal Function (2010, background): “Prolonged effects of stress on new neuron production (Heine et al. 2004, Malberg & Duman 2003, Pham et al. 2003) and survival (Koo & Duman 2008, Thomas et al. 2007, Westenbroek et al. 2004) have been observed.”
• Stress and the brain: from adaptation to disease (2005, background): “Whereas acute stress only temporarily suppressed proliferation and increased apoptotic cell death, chronic exposure to elevated corticosteroid levels caused a longer-lasting reduction in proliferation and survival, although a partial reversal was seen after several weeks of recover”
• Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression (2005, background): “It is only after prolonged stress that lasting effects on structural parameters and adult cell proliferation become apparent (Pham et al., 2003; Heine et al., 2004a).”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “, 2005), acute and chronic restraint stress (Pham et al., 2003; Vollmayr et al., 2003; Rosenbrock et al., 2005), footshock stress (Malberg and Duman, 2003; Vollmayr et al.”
• The stress system in the human brain in depression and neurodegeneration. (2005, background): “Indeed, alterations in DG turnover occur prior to stress effects on the CA3 dendritic trees, that need more time to develop and are longer lasting (Heine et al., 2004b; Pham et al., 2003).”
• The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, positive): “Two of these studies found no effects of chronic unpredictable stress or daily restraint (Pham et al., 2003; Heine et al., 2004), but both of these studies looked at cell survival 22 days after BrdU injection, and so are consistent with the lack of effect observed at 21 days in the current study.”
• Stress and adult neurogenesis (2006, background): “Certain stress paradigms, such as restraint stress (Pham et al., 2003) and active avoidance shock training (Van der Borght et al., 2005), have been shown to elevate corticosterone levels and have no measurable effect on cell proliferation.”
• Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “, 1997), acute and chronic restraint stress (Pham et al., 2003; Vollmayr et al., 2003; Rosenbrock et al., 2005), footshock stress (Malberg and Duman, 2003; Vollmayr et al.”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “At that time, the newly born cells express DCX and NeuN markers .”
• Antidepressants increase neural progenitor cells in the human hippocampus (2009, background): “In rodents, stress decreases neurogenesis while antidepressants (Dranovsky and Hen 2006), environmental enrichment, exercise (Kempermann et al, 1998; van Praag et al, 1999) and learning (Leuner et al, 2004) stimulate neurogenesis.”