The chronic mild stress (CMS) model of depression: History, evaluation and usage

By P. Willner. Neurobiology of Stress, 2016

845 citations recorded by the source corpus.

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in >1300 published studies, with a year-on-year increase rising to >200 papers in 2015. Data from a survey of users show that while a variety of names are in use (chronic mild/unpredictable/varied stress), these describe essentially the same procedure. This paper provides an update on the validity and reliability of the CMS model, and reviews recent data on the neurobiological basis of CMS effects and the mechanisms of antidepressant action: the volume of this research may be unique in providing a comprehensive account of antidepressant action within a single model. Also discussed is the use of CMS in drug discovery, with particular reference to hippocampal and extra-hippocampal targets. The high translational potential of the CMS model means that the neurobiological mechanisms described may be of particular relevance to human depression and mechanisms of clinical antidepressant action.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/2aaac7febec289212be879cdd202687f2ec05df3

How researchers see this paper

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In Behavioral Neuroscience

1. Monika Bijata
2. Svitlana Antoniuk
3. Anthony A. Grace
4. J. Włodarczyk
5. P. Belujon
6. E. Ponimaskin

In Biological Psychiatry

1. Monika Bijata
2. Svitlana Antoniuk
3. Anthony A. Grace
4. J. Włodarczyk
5. P. Belujon
6. E. Ponimaskin

In Pharmacology

1. P. Belujon
2. Monika Bijata
3. Svitlana Antoniuk
4. Anthony A. Grace
5. J. Włodarczyk
6. E. Ponimaskin

Citations in the corpus

• Chronic unpredictable mild stress for modeling depression in rodents: Meta‐analysis of model reliability (2019, positive): “…CUMS paradigm to evaluate depressive-like behavior in rodents and identify strain-specific susceptibility to stress based on one of the main end points of this model, “anhedonia,” assessed by the sucrose preference test (Willner et al., 1987; Willner, 2017b) and sucrose intake (Papp et al., 1994).”
• Dopamine System Dysregulation in Major Depressive Disorders (2017, methodology): “There has been extensive research on the anatomical and physiological modifications observed in rodents exposed to the CMS procedure that are similar to the changes observed in MDD patients (Hill et al., 2012) and described in detail in Willner’s review in 2017 (Willner, 2017).”